Structure of PDB 8uvs Chain 1N

Receptor sequence

>8uvs1N (length=140) Species: 300852 (Thermus thermophilus HB8) [Search protein sequence]

MKTYVPKQVEPRWVLIDAEGKTLGRLATKIATLLRGKHRPDWTPNVAMGD
FVVVVNADKIRVTGKKLEQKIYTRYSGYPGGLKKIPLEKMLATHPERVLE
HAVKGMLPKGPLGRRLFKRLKVYAGPDHPHQAQRPEKLEV

3D structure

PDB

8uvs Development of 2nd generation aminomethyl spectinomycins that overcome native efflux in Mycobacterium abscessus.

Chain

Resolution

2.75 Å

3D
structure

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)
BS01	rna	1N	K2 T3 W13 G24 R25 T28 R35 K37 N45 F51 T63 K65 K66 K70 R74 Y75 S76 Y78 P79 G80 L82 K83 R97 E100 H101 A102 G105 M106 P111 L112 R114 K118 H130 Q133	K2 T3 W13 G24 R25 T28 R35 K37 N45 F51 T63 K65 K66 K70 R74 Y75 S76 Y78 P79 G80 L82 K83 R97 E100 H101 A102 G105 M106 P111 L112 R114 K118 H130 Q133
BS02	MG	1N	R35 A47 L116	R35 A47 L116
BS03	MG	1N	G64 K65 L67	G64 K65 L67

External links

PDB	RCSB:8uvs, PDBe:8uvs, PDBj:8uvs
PDBsum	8uvs
PubMed	38165935
UniProt	P60488\|RL13_THET8 Large ribosomal subunit protein uL13 (Gene Name=rplM)