Structure of PDB 8vty Chain 1H

Receptor sequence
>8vty1H (length=174) Species: 300852 (Thermus thermophilus HB8) [Search protein sequence]
SRIGRLPIPVPKGVSVEVAPGRVKVKGPKGELEVPVSPEMRVVVEEGVVR
VERPSDERRHKSLHGLTRTLIANAVKGVSEGYSKELLIKGIGYRARLVGR
ALELTVGFSHPVVVEPPEGITFEVPEPTRVRVSGIDKQKVGQVAANIRAI
RKPSAYHEKGIYYAGEPVRLKPGK
3D structure
PDB8vty Macrolones target bacterial ribosomes and DNA gyrase and can evade resistance mechanisms.
Chain1H
Resolution2.6 Å
3D
structure
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Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 rna 1H S2 R3 I4 R59 K62 S63 G66 L67 T70 K85 F109 S110 H111 K138 Q139 G142 Q143 R152 Y157 H158 K160 K172 K175 S1 R2 I3 R58 K61 S62 G65 L66 T69 K84 F108 S109 H110 K137 Q138 G141 Q142 R151 Y156 H157 K159 K171 K174
External links
PDB RCSB:8vty, PDBe:8vty, PDBj:8vty
PDBsum8vty
PubMed39039256
UniProtP0DOY8|RL6_THET8 Large ribosomal subunit protein uL6 (Gene Name=rplF)

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