Structure of PDB 8vty Chain 1G

Receptor sequence

>8vty1G (length=181) Species: 300852 (Thermus thermophilus HB8) [Search protein sequence]

PLDVALKRKYYEEVRPELIRRFGYQNVWEVPRLEKVVINQGLGEAKEDAR
ILEKAAQELALITGQKPAVTRAKKSISNFKLRKGMPIGLRVTLRRDRMWI
FLEKLLNVALPRIRDFRGLNPNSFDGRGNYNLGLREQLIFPEITYDMVDA
LRGMDIAVVTTAETDEEARALLELLGFPFRK

3D structure

PDB

8vty Macrolones target bacterial ribosomes and DNA gyrase and can evade resistance mechanisms.

Chain

Resolution

2.6 Å

3D
structure

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Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)
BS01	rna	1G	K36 V38 N40 G42 L43 G44 K47 T71 A73 K74 I77 F80 L82 R91 S124 D126 R128 N132 G134 L135 G154 M155 D156	K35 V37 N39 G41 L42 G43 K46 T70 A72 K73 I76 F79 L81 R90 S123 D125 R127 N131 G133 L134 G153 M154 D155
BS02	rna	1G	P2 N27 W29 E30 Q66 K67 A69 V70 V92 T93 R95 R96 R98	P1 N26 W28 E29 Q65 K66 A68 V69 V91 T92 R94 R95 R97
BS03	MG	1G	L139 F141	L138 F140
BS04	MG	1G	R128 G129 N130 T161	R127 G128 N129 T160

External links

PDB	RCSB:8vty, PDBe:8vty, PDBj:8vty
PDBsum	8vty
PubMed	39039256
UniProt	Q5SHQ0\|RL5_THET8 Large ribosomal subunit protein uL5 (Gene Name=rplE)

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