Structure of PDB 8vtw Chain 1G

Receptor sequence

>8vtw1G (length=181) Species: 300852 (Thermus thermophilus HB8) [Search protein sequence]

PLDVALKRKYYEEVRPELIRRFGYQNVWEVPRLEKVVINQGLGEAKEDAR
ILEKAAQELALITGQKPAVTRAKKSISNFKLRKGMPIGLRVTLRRDRMWI
FLEKLLNVALPRIRDFRGLNPNSFDGRGNYNLGLREQLIFPEITYDMVDA
LRGMDIAVVTTAETDEEARALLELLGFPFRK

3D structure

PDB

8vtw Macrolones target bacterial ribosomes and DNA gyrase and can evade resistance mechanisms.

Chain

Resolution

2.35 Å

3D
structure

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Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)
BS01	rna	1G	K36 V38 N40 G42 L43 E45 T71 A73 K74 I77 N79 F80 I88 R91 S124 D126 R128 N132 G134 L135 G154 D156 A158	K35 V37 N39 G41 L42 E44 T70 A72 K73 I76 N78 F79 I87 R90 S123 D125 R127 N131 G133 L134 G153 D155 A157
BS02	rna	1G	P2 N27 W29 E30 Q66 K67 A69 V70 R72 R91 V92 T93 R95 R96 R98	P1 N26 W28 E29 Q65 K66 A68 V69 R71 R90 V91 T92 R94 R95 R97
BS03	MG	1G	L139 F141	L138 F140
BS04	MG	1G	N123 F125	N122 F124
BS05	MG	1G	R128 N130 T161	R127 N129 T160

External links

PDB	RCSB:8vtw, PDBe:8vtw, PDBj:8vtw
PDBsum	8vtw
PubMed	39039256
UniProt	Q5SHQ0\|RL5_THET8 Large ribosomal subunit protein uL5 (Gene Name=rplE)

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