Structure of PDB 8uep Chain 1G

Receptor sequence

>8uep1G (length=699) Species: 9823 (Sus scrofa)

SNLIEVFVDGQSVMVEPGTTVLQACEKVGMQIPRFCYHERLSVAGNCRMC
LVEIEKAPKVVAACAMPVMKGWNILTNSEKSKKAREGVMEFLLANHPLDC
PICDQGGECDLQDQSMMFGSDRSRFLEGKRAVEDKNIGPLVKTIMTRCIQ
CTRCIRFASEIAGVDDLGTTGRGNDMQVGTYIEKMFMSELSGNIIDICPV
GALTSKPYAFTARPWETRKTESIDVMDAVGSNIVVSTRTGEVMRILPRMH
EDINEEWISDKTRFAYDGLKRQRLTQPMIRNEKGLLTYTTWEDALSRVAG
MLQSFQGNDVAAIAGGLVDAEALVALKDLLNRVDSDSLCTEEVFPTAGAG
TDLRSNYLLNTTIAGVEEADVILLVGTNPRFEAPLFNARIRKSWLHNDLK
VALIGSPVDLTYRYDHLGDSPKILQDIASGNHPFSQILKEAKKPMVVLGS
SALQRSDGTAILAAVSNIAQNIRLSSGVTGDWKVMNILHRIASQVAALDL
GYKPGVEAIRKNPPKVLFLLGADGGCITRQDLPKDCFIIYQGHHGDVGAP
MADVILPGAAYTEKSATYVNTEGRAQQTKVAVTPPGLAREDWKIIRALSE
IAGMTLPYDTLDQVRSRLEEVSPNLVRYDDVEGANYFQQANELSKLVNQQ
LLADPLVPPQLTIKDFYMTDSISRASQTMAKCVKAVTEGIQAVEEPSIC

3D structure

• PDB: 8uep High-resolution in situ structures of mammalian respiratory supercomplexes.
• Chain: 1G
• Resolution: 3.4 Å

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	SF4	1G	H101 D104 C105 C108 Q110 G111 C114 Q117 V205 G206	H96 D99 C100 C103 Q105 G106 C109 Q112 V200 G201
BS02	SF4	1G	C153 I154 Q155 C156 T157 C159 V183 C203 A207	C148 I149 Q150 C151 T152 C154 V178 C198 A202
BS03	FES	1G	C41 G50 C52 R53 C55 C69	C36 G45 C47 R48 C50 C64

Gene Ontology

Molecular Function

• GO:0046872 metal ion binding
• GO:0051539 4 iron, 4 sulfur cluster binding

Biological Process

• GO:1902600 proton transmembrane transport

Cellular Component

• GO:0005743 mitochondrial inner membrane

External links

• PDB: RCSB:8uep, PDBe:8uep, PDBj:8uep
• PDBsum: 8uep
• PubMed: 38811722
• UniProt: A0A287ARY3