Structure of PDB 8vtu Chain 18

Receptor sequence

>8vtu18 (length=64) Species: 300852 (Thermus thermophilus HB8) [Search protein sequence]

PKMKTHKGAKKRVKITASGKVVAMKTGKRHLNWQKSGKEIRQKGRKFVLA
KPEAERIKLLLPYE

3D structure

PDB

8vtu Macrolones target bacterial ribosomes and DNA gyrase and can evade resistance mechanisms.

Chain

Resolution

2.4 Å

3D
structure

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)
BS01	rna	18	P2 K3 M4 K5 T6 H7 K8 K12 R13 K15 T17 A18 S19 K26 T27 G28 K29 R30 H31 L32 N33 W34 Q35 K39 I41 R42 Q43 K44 R46 K47 F48 A51 K52 E54 Y64	P1 K2 M3 K4 T5 H6 K7 K11 R12 K14 T16 A17 S18 K25 T26 G27 K28 R29 H30 L31 N32 W33 Q34 K38 I40 R41 Q42 K43 R45 K46 F47 A50 K51 E53 Y63
BS02	MG	18	K8 G9	K7 G8
BS03	MG	18	L32 W34	L31 W33
BS04	MG	18	S37 G38	S36 G37
BS05	MG	18	L60 P63	L59 P62

External links

PDB	RCSB:8vtu, PDBe:8vtu, PDBj:8vtu
PDBsum	8vtu
PubMed	39039256
UniProt	Q5SKU1\|RL35_THET8 Large ribosomal subunit protein bL35 (Gene Name=rpmI)