Structure of PDB 8vtw Chain 15

Receptor sequence

>8vtw15 (length=59) Species: 300852 (Thermus thermophilus HB8) [Search protein sequence]

AKHPVPKKKTSKARRDARRSHHALTPPTLVPCPECKAMKPPHTVCPECGY
YAGRKVLEV

3D structure

PDB

8vtw Macrolones target bacterial ribosomes and DNA gyrase and can evade resistance mechanisms.

Chain

Resolution

2.35 Å

3D
structure

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)
BS01	rna	15	A2 K3 H4 P5 V6 P7 K8 K9 K10 T11 S12 K13 A14 R15 R16 D17 A18 R19 R20 S21 H22 H23 T29 V31 P34 P42 H43 Y52 A53	A1 K2 H3 P4 V5 P6 K7 K8 K9 T10 S11 K12 A13 R14 R15 D16 A17 R18 R19 S20 H21 H22 T28 V30 P33 P41 H42 Y51 A52
BS02	MG	15	R15 R19	R14 R18
BS03	MG	15	V6 K8	V5 K7
BS04	ZN	15	C33 C36 C46 C49	C32 C35 C45 C48

External links

PDB	RCSB:8vtw, PDBe:8vtw, PDBj:8vtw
PDBsum	8vtw
PubMed	39039256
UniProt	P80339\|RL32_THET8 Large ribosomal subunit protein bL32 (Gene Name=rpmF)