Structure of PDB 8i0s Chain 1

Receptor sequence
>8i0s1 (length=816) Species: 9606 (Homo sapiens) [Search protein sequence]
PEEQKERKIMKLLLKIKNGTPPMRKAALRQITDKAREFGAGPLFNQILPL
LMSPTLEDQERHLLVKVIDRILYKLDDLVRPYVHKILVVIEPLLIDEDYY
ARVEGREIISNLAKAAGLATMISTMRPDIDNMDEYVRNTTARAFAVVASA
LGIPSLLPFLKAVCKSKKSWQARHTGIKIVQQIAILMGCAILPHLRSLVE
IIEHGLVDEQQKVRTISALAIAALAEAATPYGIESFDSVLKPLWKGIRQH
RGKGLAAFLKAIGYLIPLMDAEYANYYTREVMLILIREFQSPDEEMKKIV
LKVVKQCCGTDGVEANYIKTEILPPFFKHFWQHRMALDRRNYRQLVDTTV
ELANKVGAAEIISRIVDDLKDEAEQYRKMVMETIEKIMGNLGAADIDHKL
EEQLIDGILYAFQEQTTEDSVMLNGFGTVVNALGKRVKPYLPQICGTVLW
RLNNKSAKVRQQAADLISRTAVVMKTCQEEKLMGHLGVVLYEYLGEEYPE
VLGSILGALKAIVNVIGMHKMTPPIKDLLPRLTPILKNRHEKVQENCIDL
VGRIADRGAEYVSAREWMRICFELLELLKAHKKAIRRATVNTFGYIAKAI
GPHDVLATLLNNLKVQERQNRVCTTVAIAIVAETCSPFTVLPALMNEYRV
PELNVQNGVLKSLSFLFEYIGEMGKDYIYAVTPLLEDALMDRDLVHRQTA
SAVVQHMSLGVYGFGCEDSLNHLLNYVWPNVFETSPHVIQAVMGALEGLR
VAIGPCRMLQYCLQGLFHPARKVRDVYWKIYNSIYIGSQDALIAHYPRIY
NDDKNTYIRYELDYIL
3D structure
PDB8i0s Molecular Basis for the Activation of Human Spliceosome
Chain1
Resolution4.2 Å
3D
structure
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Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 rna 1 H1069 K1070 R1075 Q1104 V1110 H1225 H581 K582 R587 Q616 V622 H737
BS02 rna 1 P1257 A1258 P769 A770
Gene Ontology
Molecular Function
GO:0003723 RNA binding
GO:0003729 mRNA binding
GO:0005515 protein binding
GO:1990935 splicing factor binding
Biological Process
GO:0000245 spliceosomal complex assembly
GO:0000375 RNA splicing, via transesterification reactions
GO:0000398 mRNA splicing, via spliceosome
GO:0006338 chromatin remodeling
GO:0006397 mRNA processing
GO:0008380 RNA splicing
GO:0045943 positive regulation of transcription by RNA polymerase I
GO:0045944 positive regulation of transcription by RNA polymerase II
GO:0045945 positive regulation of transcription by RNA polymerase III
GO:1903241 U2-type prespliceosome assembly
Cellular Component
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005681 spliceosomal complex
GO:0005684 U2-type spliceosomal complex
GO:0005686 U2 snRNP
GO:0005689 U12-type spliceosomal complex
GO:0005730 nucleolus
GO:0016607 nuclear speck
GO:0034693 U11/U12 snRNP
GO:0071004 U2-type prespliceosome
GO:0071005 U2-type precatalytic spliceosome
GO:0071013 catalytic step 2 spliceosome
GO:0110016 B-WICH complex

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:8i0s, PDBe:8i0s, PDBj:8i0s
PDBsum8i0s
PubMed39068178
UniProtO75533|SF3B1_HUMAN Splicing factor 3B subunit 1 (Gene Name=SF3B1)

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