Structure of PDB 7tut Chain 1

Receptor sequence
>7tut1 (length=465) Species: 9612 (Canis lupus) [Search protein sequence]
MAIKFLEVIKPFCVILPEIQKPERKIQFKEKVLWTAITLFIFLVCCQIPL
FGIMSSDSADPFYWMRVILASNRGTLMELGISPIVTSGLIMQLLAGAKII
EVGDTPKDRALFNGAQKLFGMIITIGQSIVYVMTGMYGDPSEMGAGICLL
ITIQLFVAGLIVLLLDELLQKGYGLGSGISLFIATNICETIVWKAFSPTT
VNTGRGMEFEGAIIALFHLLATRTDKVRALREAFYRQNLPNLMNLIATIF
VFAVVIYFQGFRVDLPIKSARYRGQYNTYPIKLFYTSNIPIILQSALVSN
LYVISQMLSARFSGNLLVSLLGTWSDTSSGGPARAYPVGGLCHYLSPPES
FGSVLEDPVHAVVYIVFMLGSCAFFSKTWIEVSGSSAKDVAKQLKEQQMV
MRGHRETSMVHELNRYIPTAAAFGGLCIGALSVLADFLGAIGSGTGILLA
VTIIYQYFEIFVKEQ
3D structure
PDB7tut Mechanism of an intramembrane chaperone for multipass membrane proteins.
Chain1
Resolution3.88 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide 1 W34 I48 F51 L76 V157 I161 L168 W34 I48 F51 L76 V157 I161 L168
BS02 rna 1 K268 A270 R273 G403 R405 K268 A270 R273 G403 R405
Gene Ontology
Molecular Function
GO:0005048 signal sequence binding
GO:0005515 protein binding
GO:0008320 protein transmembrane transporter activity
GO:0043022 ribosome binding
Biological Process
GO:0006613 cotranslational protein targeting to membrane
GO:0006616 SRP-dependent cotranslational protein targeting to membrane, translocation
GO:0015031 protein transport
GO:0031204 post-translational protein targeting to membrane, translocation
GO:0039019 pronephric nephron development
GO:0045047 protein targeting to ER
GO:0045048 protein insertion into ER membrane
Cellular Component
GO:0005783 endoplasmic reticulum
GO:0005784 Sec61 translocon complex
GO:0005789 endoplasmic reticulum membrane
GO:0016020 membrane

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:7tut, PDBe:7tut, PDBj:7tut
PDBsum7tut
PubMed36261528
UniProtP38377|S61A1_CANLF Protein transport protein Sec61 subunit alpha isoform 1 (Gene Name=SEC61A1)

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