Structure of PDB 6h8k Chain 1

Receptor sequence
>6h8k1 (length=325) Species: 4952 (Yarrowia lipolytica) [Search protein sequence]
MIINIVEILIFLVCVLFSVAYLTVAERKTLAYMQRRLGPNFVGYYGLLQA
FADAVKLLLKEIVLPESNYIILVISPLITLITALIGWVVIPLGPGITLGE
LNLGILFSLAIGSLGVFGSLLSGWSSNSKYSLLGSIRSTAQLISYELILT
SIFIIIIMFVSSLNITTIIETQRVVWYCIPLLPLLLIFFIASVAETARPP
FDLTESESELVSPFVFFFLAEYSNIILISAFNGYLLLGGYLSFNYSYLFN
ILFNDYSYVSFLFEGLINSSAYAIKLVFLMFSFIWVRAAFPRFTYDNLIN
FCWIILLPLLFGIFLIIPSTLYIFD
3D structure
PDB6h8k Locking loop movement in the ubiquinone pocket of complex I disengages the proton pumps.
Chain1
Resolution3.79 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 7.1.1.2: NADH:ubiquinone reductase (H(+)-translocating).
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide 1 C14 S18 Y21 K28 I97 S279 A283 C14 S18 Y21 K28 I96 S269 A273
BS02 peptide 1 L262 Y266 S267 L252 Y256 S257
Gene Ontology
Molecular Function
GO:0003954 NADH dehydrogenase activity
GO:0008137 NADH dehydrogenase (ubiquinone) activity
Biological Process
GO:0009060 aerobic respiration
GO:1902600 proton transmembrane transport
Cellular Component
GO:0005739 mitochondrion
GO:0005743 mitochondrial inner membrane
GO:0016020 membrane
GO:0045271 respiratory chain complex I

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External links
PDB RCSB:6h8k, PDBe:6h8k, PDBj:6h8k
PDBsum6h8k
PubMed30374105
UniProtQ9B6E8|NU1M_YARLI NADH-ubiquinone oxidoreductase chain 1 (Gene Name=ND1)

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