Structure of PDB 6fo8 Chain 1

Receptor sequence
>6fo81 (length=236) Species: 7955 (Danio rerio) [Search protein sequence]
LSDEQMQIINSLVEAHHKTYDDSYSDFVRFRPPVRRLSMLPHLADLVSYS
IQKVIGFAKMIPGFRDLTAEDQIALLKSSAIEIIMLRSNQSFSLEDMSWS
CGGPDFKYCINDVTKAGHTLELLEPLVKFQVGLKKLKLHEEEHVLLMAIC
LLSPDRPGVQDHVRIEALQDRLCDVLQAYIRIQHPGGRLLYAKMIQKLAD
LRSLNEEHSKQYRSLSFQPEHSMQLTPLVLEVFGSE
3D structure
PDB6fo8 Aromatic-Based Design of Highly Active and Noncalcemic Vitamin D Receptor Agonists.
Chain1
Resolution2.3 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide 1 I270 K274 I288 K292 E446 E451 I55 K59 I73 K77 E231 E236
BS02 DZT 1 Y175 L258 L261 S265 I296 I299 R302 S303 S306 W314 C316 Y323 H333 H423 Y20 L43 L46 S50 I81 I84 R87 S88 S91 W99 C101 Y108 H118 H208 MOAD: ic50=18.4nM
PDBbind-CN: -logKd/Ki=7.74,IC50=18.4nM
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0004879 nuclear receptor activity
Biological Process
GO:0006355 regulation of DNA-templated transcription
Cellular Component
GO:0005634 nucleus

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Cellular Component
External links
PDB RCSB:6fo8, PDBe:6fo8, PDBj:6fo8
PDBsum6fo8
PubMed29733645
UniProtQ9PTN2|VDRA_DANRE Vitamin D3 receptor A (Gene Name=vdra)

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