Structure of PDB 5iy5 Chain 1

Receptor sequence

>5iy51 (length=104) Species: 9796 (Equus caballus)

GDVEKGKKIFVQKCAQCHTVEKGGKHKTGPNLHGLFGRKTGQAPGFTYTD
ANKNKGITWKEETLMEYLENPKKYIPGTKMIFAGIKKKTEREDLIAYLKK
ATNE

3D structure

• PDB: 5iy5 Complex structure of cytochrome c-cytochrome c oxidase reveals a novel protein-protein interaction mode
• Chain: 1
• Resolution: 2.0 Å

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	HEC	1	C14 C17 H18 G29 P30 T40 G41 Y48 T49 N52 W59 Y67 L68 T78 K79 M80 F82	C14 C17 H18 G29 P30 T40 G41 Y48 T49 N52 W59 Y67 L68 T78 K79 M80 F82

Gene Ontology

Molecular Function

• GO:0005515 protein binding
• GO:0008289 lipid binding
• GO:0009055 electron transfer activity
• GO:0020037 heme binding
• GO:0042802 identical protein binding
• GO:0046872 metal ion binding

Biological Process

• GO:0006122 mitochondrial electron transport, ubiquinol to cytochrome c
• GO:0006123 mitochondrial electron transport, cytochrome c to oxygen
• GO:0006915 apoptotic process
• GO:0018063 cytochrome c-heme linkage
• GO:0043065 positive regulation of apoptotic process
• GO:0043280 positive regulation of cysteine-type endopeptidase activity involved in apoptotic process
• GO:2001056 positive regulation of cysteine-type endopeptidase activity

Cellular Component

• GO:0005739 mitochondrion
• GO:0005758 mitochondrial intermembrane space
• GO:0005829 cytosol
• GO:0070069 cytochrome complex

External links

• PDB: RCSB:5iy5, PDBe:5iy5, PDBj:5iy5
• PDBsum: 5iy5
• PubMed: 27979921
• UniProt: P00004|CYC_HORSE Cytochrome c (Gene Name=CYCS)