Structure of PDB 3jc2 Chain 1

Receptor sequence
>3jc21 (length=401) Species: 9615 (Canis lupus familiaris) [Search protein sequence]
PFCVILPEIQKPERKIQFKEKVLWTAITLFIFLVCCQIPLFGIGTLMELG
ISPIVTSGLIMQLLAGAKIIEVGDTPKDRALFNGAQKLFGMIITIGQSIV
YVMTGICLLITIQLFVAGLIVLLLDELLQKGYGLGSGISLFIATNICETI
VWKAFSPTTVNTGRGMEFEGAIIALFHLLATRTDKVRALREAFYRQNLPN
LMNLIATIFVFAVVIYFQGFRVDLPIKSARYRGQYNTYPIKLFYTSNIPI
ILQSALVSNLYVISQMLSARFPVGGLCHYLSPPESFGSVLEDPVHAVVYI
VFMLGSCAFFSKTWIEVSGSSAKDVAKQLKEQQMVMRGHRETSMVHELNR
YIPTAAAFGGLCIGALSVLADFLGAIGSGTGILLAVTIIYQYFEIFVKEQ
S
3D structure
PDB3jc2 Structure of the Sec61 channel opened by a signal sequence.
Chain1
Resolution3.6 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide 1 I90 Q127 L297 N300 L301 F375 I60 Q97 L256 N259 L260 F310
Gene Ontology
Molecular Function
GO:0005048 signal sequence binding
GO:0005515 protein binding
GO:0008320 protein transmembrane transporter activity
GO:0043022 ribosome binding
Biological Process
GO:0006613 cotranslational protein targeting to membrane
GO:0006616 SRP-dependent cotranslational protein targeting to membrane, translocation
GO:0015031 protein transport
GO:0031204 post-translational protein targeting to membrane, translocation
GO:0039019 pronephric nephron development
GO:0045047 protein targeting to ER
GO:0045048 protein insertion into ER membrane
Cellular Component
GO:0005783 endoplasmic reticulum
GO:0005784 Sec61 translocon complex
GO:0005789 endoplasmic reticulum membrane
GO:0016020 membrane

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:3jc2, PDBe:3jc2, PDBj:3jc2
PDBsum3jc2
PubMed26721998
UniProtP38377|S61A1_CANLF Protein transport protein Sec61 subunit alpha isoform 1 (Gene Name=SEC61A1)

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