Structure of PDB 3crw Chain 1

Receptor sequence
>3crw1 (length=485) Species: 2285 (Sulfolobus acidocaldarius) [Search protein sequence]
EKLKDKVIEGLRNNFLVALNAPTGSGKTLFSLLVSLEVKPKVLFVVRTHN
EFYPIYRDLTKIREITFSFLVGKPSSCLESENSLYKADVIALTYPYFFID
RYREFIDIDLREYMIVIDEAHNLDKVNELEERSLSEITIQMAIKQSKSEE
SRRILSKLLNQLREVVLPDEKYIKVENVPKLSKEELEILADDYEDIRKDS
LKQKIHIGSILRFFSLLSIGSFIPFSYSKRLVIKNPEISYYLNLLNDNEL
SIILMSGTLPPREYMEKVWGIKRNMLYLDVEREIQKRVSGSYECYIGVDV
TSKYDMRSDNMWKRYADYLLKIYFQAKANVLVVFPSYEIMDRVMSRISLP
KYVESEDSSVEDLYSAISANNKVLIGSVGKGKLAEGIELRNNDRSLISDV
VIVGIPYPPPDDYLKILAQRVSLKMNRENEEFLFKIPALVTIKQAIGRAI
RDVNDKCNVWLLDKRFESLYWKKNLKCLNANKMKL
3D structure
PDB3crw XPD helicase structures and activities: insights into the cancer and aging phenotypes from XPD mutations.
Chain1
Resolution4.0 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.6.4.12: DNA helicase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 FC6 1 K233 Y370 R373 P475 P476 K171 Y304 R307 P409 P410
Gene Ontology
Molecular Function
GO:0003676 nucleic acid binding
GO:0003677 DNA binding
GO:0003678 DNA helicase activity
GO:0004386 helicase activity
GO:0005524 ATP binding
GO:0016787 hydrolase activity
GO:0016818 hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides
GO:0016853 isomerase activity
GO:0016887 ATP hydrolysis activity
GO:0043139 5'-3' DNA helicase activity
GO:0046872 metal ion binding
GO:0051539 4 iron, 4 sulfur cluster binding
GO:0140097 catalytic activity, acting on DNA
Biological Process
GO:0006139 nucleobase-containing compound metabolic process
GO:0006281 DNA repair
GO:0032508 DNA duplex unwinding
GO:0071103 DNA conformation change

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Molecular Function
View graph for
Biological Process
External links
PDB RCSB:3crw, PDBe:3crw, PDBj:3crw
PDBsum3crw
PubMed18510924
UniProtQ4JC68|XPD_SULAC ATP-dependent DNA helicase XPD (Gene Name=xpd)

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