Structure of PDB 2hy8 Chain 1

Receptor sequence
>2hy81 (length=293) Species: 9606 (Homo sapiens) [Search protein sequence]
SDEEILEKLRSIVSVGDPKKKYTRFEKIGQGASGTVYTAMDVATGQEVAI
RQMNLQQQPKKELIINEILVMRENKNPNIVNYLDSYLVGDELWVVMEYLA
GGSLTDVVTETCMDEGQIAAVCRECLQALEFLHSNQVIHRDIKSDNILLG
MDGSVKLTDFGFCAQITPEQSKRSEMVGTPYWMAPEVVTRKAYGPKVDIW
SLGIMAIEMIEGEPPYLNENPLRALYLIATNGTPELQNPEKLSAIFRDFL
NRCLDMDVEKRGSAKELLQHQFLKIAKPLSSLTPLIAAAKEAT
3D structure
PDB2hy8 Crystal Structure of the Complex Between Human Pak1-kinase and 3-Hydroxystaurosporine
Chain1
Resolution2.0 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) N394 D407 T427
Catalytic site (residue number reindexed from 1) N146 D159 T179
Enzyme Commision number 2.7.11.1: non-specific serine/threonine protein kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 1ST 1 I276 V284 A297 R299 V328 M344 E345 Y346 L347 D393 L396 I28 V36 A49 R51 V80 M96 E97 Y98 L99 D145 L148
Gene Ontology
Molecular Function
GO:0004672 protein kinase activity
GO:0005524 ATP binding
Biological Process
GO:0006468 protein phosphorylation

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Molecular Function
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Biological Process
External links
PDB RCSB:2hy8, PDBe:2hy8, PDBj:2hy8
PDBsum2hy8
PubMed
UniProtQ13153|PAK1_HUMAN Serine/threonine-protein kinase PAK 1 (Gene Name=PAK1)

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