Structure of PDB 2hwe Chain 1

Receptor sequence
>2hwe1 (length=283) Species: 12134 (Human rhinovirus 1A) [Search protein sequence]
NYIDEVLNEVLVVPNIKESHHTTSNSAPLLDAAETGHTSNVQPEDAIETR
YVITSQTRDEMSIESFLGRSGCVHISRIKVDYTDYNGQDINFTKWKITLQ
EMAQIRRKFELFTYVRFDSEITLVPCIAGRGDDIGHIVMQYMYVPPGAPI
PSKRNDFSWQSGTNMSIFWQHGQPFPRFSIPFLSIASAYYMFYDGYDGDN
TSSKYGSVVTNDMGTICSRIVTEKQKLSVVITTHIYHKAKHTKAWCPRPP
RAVPYTHSHVTNYMPETGDVTTAIVRRNTITTA
3D structure
PDB2hwe A comparison of the anti-rhinoviral drug binding pocket in HRV14 and HRV1A.
Chain1
Resolution3.8 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.7.7.48: RNA-directed RNA polymerase.
3.4.22.28: picornain 3C.
3.4.22.29: picornain 2A.
3.6.1.15: nucleoside-triphosphate phosphatase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide 1 N5 E9 V14 L15 D63 E68 D122 P185 K244 H245 N1 E5 V10 L11 D59 E64 D118 P181 K240 H241
BS02 W54 1 L103 I125 Y145 M146 Y147 I220 L99 I121 Y141 M142 Y143 I216
Gene Ontology
Molecular Function
GO:0005198 structural molecule activity

View graph for
Molecular Function
External links
PDB RCSB:2hwe, PDBe:2hwe, PDBj:2hwe
PDBsum2hwe
PubMed8383771
UniProtP23008|POLG_HRV1A Genome polyprotein

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