Structure of PDB 8pj5 Chain 0

Receptor sequence

>8pj50 (length=622) Species: 9606 (Homo sapiens)

RTKEERAYDKAKRRIEKRRLEHSKNVNTEKLRAPIICVLGHVDTGKTKIL
DKLRHTHVQDGEAGGITQQIGATNVPLEAINEQTKMIKNFDRENVRIPGM
LIIDTPGHESFSNLRNRGSSLCDIAILVVDIMHGLEPQTIESINLLKSKK
CPFIVALNKIDRLYDWKKSPDSDVAATLKKQKKNTKDEFEERAKAIIVEF
AQQGLNAALFYENKDPRTFVSLVPTSAHTGDGMGSLIYLLVELTQTMLSK
RLAHCEELRAQVMEVKALPGMGTTIDVILINGRLKEGDTIIVPGVEGPIV
TQIRGLLLPPPMKELRVKNQYEKHKEVEAAQGVKILGKDLEKTLAGLPLL
VAYKEDEIPVLKDELIHELKQTLNAIKLEEKGVYVQASTLGSLEALLEFL
KTSEVPYAGINIGPVHKKDVMKASVMLEHDPQYAVILAFDVRIERDAQEM
ADSLGVRIFSAEIIYHLFDAFTKYRQDYKKQKQEEFKHIAVFPCKIKILP
QYIFNSRDPIVMGVTVEAGQVKQGTPMCVPSKNFVDIGIVTSIEINHKQV
DVAKKGQEVCVKIEPIPGESPKMFGRHFEATDILVSKISRQSIDALKDWF
RDEMQKSDWQLIVELKKVFEII

3D structure

• PDB: 8pj5 Structural basis for translational control by the human 48S initiation complex from codon scanning toward subunit joining
• Chain: 0
• Resolution: 2.9 Å

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	rna	0	G868 M869 G870 R902 K921 K936 H1014 K1015 K1016 R1040 R1043	G270 M271 G272 R304 K323 K338 H416 K417 K418 R442 R445
BS02	rna	0	F1102 N1103 S1104 R1105 S1140 E1142 C1158 K1160 E1167 S1168 R1174	F504 N505 S506 R507 S542 E544 C560 K562 E569 S570 R576
BS03	MG	0	T645 E660 T665	T47 E62 T67
BS04	GTP	0	V640 D641 T642 G643 K644 T645 I664 T665 K757 D759 S824 A825 H826	V42 D43 T44 G45 K46 T47 I66 T67 K159 D161 S226 A227 H228

External links

• PDB: RCSB:8pj5, PDBe:8pj5, PDBj:8pj5
• PDBsum: 8pj5
• UniProt: O60841|IF2P_HUMAN Eukaryotic translation initiation factor 5B (Gene Name=EIF5B)