Structure of PDB 8pj4 Chain 0

Receptor sequence

>8pj40 (length=621) Species: 9606 (Homo sapiens)

RTKEERAYDKAKRRIEKRRLEHSKNVNTEKLRAPIICVLGHVDTGKTKIL
DKLRHTHVQDGEAGGITQQIGATNVPLEAINEQTKMIKNFDRENVRIPGM
LIIDTPGHESFSNLRNRGSSLCDIAILVVDIMHGLEPQTIESINLLKSKK
CPFIVALNKIDRLYDWKKSPDSDVAATLKKQKKNTKDEFEERAKAIIVEF
AQQGLNAALFYENKDPRTFVSLVPTSAHTGDGMGSLIYLLVELTQTMLSK
RLAHCEELRAQVMEVKALPGMGTTIDVILINGRLKEGDTIIVPGVEGPIV
TQIRGLLLPPPMKELRVKNQYEKHKEVEAAQGVKILGKDLEKTLAGLPLL
VAYKEDEIPVLKDELIHELKQTLNAIKLEEKGVYVQASTLGSLEALLEFL
KTSEVPYAGINIGPVHKKDVMKASVMLEHDPQYAVILAFDVRIERDAQEM
ADSLGVRIFSAEIIYHLFDAFTKYRQDYKKQKQEEFKHIAVFPCKIKILP
QYIFNSRDPIVMGVTVEAGQVKQGTPMCVPSKNFVDIGIVTSIEINHKQV
DVAKKGQEVCVKIEPIPGESPKMFGRHFEATDILVSKISRQSIDALKDWF
RDEMQKSDWQLIVELKKVFEI

3D structure

• PDB: 8pj4 UCSF ChimeraX: Structure visualization for researchers, educators, and developers
• Chain: 0
• Resolution: 3.2 Å

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	rna	0	G868 M869 G870 R902 K916 K921 L934 K936 H1014 K1015 K1016 R1040	G270 M271 G272 R304 K318 K323 L336 K338 H416 K417 K418 R442
BS02	rna	0	N1103 S1104 R1105 P1107 V1109 S1140 E1142 N1144 H1145 C1158 K1160 E1167 S1168 R1174	N505 S506 R507 P509 V511 S542 E544 N546 H547 C560 K562 E569 S570 R576
BS03	GTP	0	V640 D641 G643 K644 T645 K646 Q657 G663 I664 T665 G705 K757 R760 A825	V42 D43 G45 K46 T47 K48 Q59 G65 I66 T67 G107 K159 R162 A227
BS04	MG	0	T645 E660 T665	T47 E62 T67

External links

• PDB: RCSB:8pj4, PDBe:8pj4, PDBj:8pj4
• PDBsum: 8pj4
• UniProt: O60841|IF2P_HUMAN Eukaryotic translation initiation factor 5B (Gene Name=EIF5B)