Structure of PDB 8pj3 Chain 0

Receptor sequence

>8pj30 (length=621) Species: 9606 (Homo sapiens)

RTKEERAYDKAKRRIEKRRLEHSKNVNTEKLRAPIICVLGHVDTGKTKIL
DKLRHTHVQDGEAGGITQQIGATNVPLEAINEQTKMIKNFDRENVRIPGM
LIIDTPGHESFSNLRNRGSSLCDIAILVVDIMHGLEPQTIESINLLKSKK
CPFIVALNKIDRLYDWKKSPDSDVAATLKKQKKNTKDEFEERAKAIIVEF
AQQGLNAALFYENKDPRTFVSLVPTSAHTGDGMGSLIYLLVELTQTMLSK
RLAHCEELRAQVMEVKALPGMGTTIDVILINGRLKEGDTIIVPGVEGPIV
TQIRGLLLPPPMKELRVKNQYEKHKEVEAAQGVKILGKDLEKTLAGLPLL
VAYKEDEIPVLKDELIHELKQTLNAIKLEEKGVYVQASTLGSLEALLEFL
KTSEVPYAGINIGPVHKKDVMKASVMLEHDPQYAVILAFDVRIERDAQEM
ADSLGVRIFSAEIIYHLFDAFTKYRQDYKKQKQEEFKHIAVFPCKIKILP
QYIFNSRDPIVMGVTVEAGQVKQGTPMCVPSKNFVDIGIVTSIEINHKQV
DVAKKGQEVCVKIEPIPGESPKMFGRHFEATDILVSKISRQSIDALKDWF
RDEMQKSDWQLIVELKKVFEI

3D structure

• PDB: 8pj3 UCSF ChimeraX: Structure visualization for researchers, educators, and developers
• Chain: 0
• Resolution: 3.7 Å

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	rna	0	M869 G870 R902 K916 K921 L934 K936 H1014 K1015 K1016 R1040 R1043	M271 G272 R304 K318 K323 L336 K338 H416 K417 K418 R442 R445
BS02	rna	0	I1101 N1103 I1108 V1109 M1171 R1174	I503 N505 I510 V511 M573 R576
BS03	GTP	0	V640 D641 G643 K644 T645 K646 Q657 G663 I664 T665 G705 K757 D759 R760 A825 H826	V42 D43 G45 K46 T47 K48 Q59 G65 I66 T67 G107 K159 D161 R162 A227 H228
BS04	MG	0	I664 T665	I66 T67

External links

• PDB: RCSB:8pj3, PDBe:8pj3, PDBj:8pj3
• PDBsum: 8pj3
• UniProt: O60841|IF2P_HUMAN Eukaryotic translation initiation factor 5B (Gene Name=EIF5B)