Structure of PDB 7nhn Chain 0

Receptor sequence

>7nhn0 (length=461) Species: 169963 (Listeria monocytogenes EGD-e) [Search protein sequence]

TIEINQLKIEVADRVLVEIPHLLVSKKARIGIIGQNGLGKTTLMEVIAGA
KEATSGTVTTQGKLAYIKQLSTDTSTKSGGEKTRKATQHAMRQNPSVLLA
DQPTSNLDVESVKHLERQWSDFHGALIIISHDRAFLDALCTEIWEIKNQK
IHVYKGNYHAYLEQKQQQENQAELAYKEFKNKKKQLQASQTHHEIEAGRI
VKPGKRLNNKEASAFKAGKGTQQKKQHSTIKALEKRIERLGNVEKPHTTK
PIKIITPDNRVIKKGNTILSAKETAYEIAGRKLFETKAFSIKAGDKVALI
GENASGKTTFLKEIIQENPNLLCNPQAKIAYFDQELNGLNQTKSLLENIS
EISVQTKQVNREVLGSMHFKESDLHKEVRMLSGGERVKLLLSMLLLSDAN
FLILDQPTNYLDIYAMEALETLIKQFAGTVLFVSHDRTFVNHVAEQLLVI
ENNEMNFHRMT

3D structure

PDB

7nhn Structural basis of ABCF-mediated resistance to pleuromutilin, lincosamide, and streptogramin A antibiotics in Gram-positive pathogens.

Chain

Resolution

2.9 Å

3D
structure

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Enzymatic activity

Enzyme Commision number

Interaction with ligand

Site #	Ligand	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)
BS01	rna	I197 K247 H249 T250 K252 P253 K255 R363 E364 G367 H370 E373	I195 K245 H247 T248 K250 P251 K253 R361 E362 G365 H368 E371
BS02	rna	K29 R86 Q90 R94 H116 R119 H125 K179 E180 Q187 S191 H194 R201 I202 K204 P205 R208 K212 E213 A214 S215 F217 G220 K221 T223 Q224 K226 K227 H229 K233 K237 R238 R241	K27 R84 Q88 R92 H114 R117 H123 K177 E178 Q185 S189 H192 R199 I200 K202 P203 R206 K210 E211 A212 S213 F215 G218 K219 T221 Q222 K224 K225 H227 K231 K235 R236 R239
BS03	rna	K265 N268 T269	K263 N266 T267
BS04	ATP	T78 S80 E83 I280 N305 A306 S307 G308 K309 T310 T311 Q336	T76 S78 E81 I278 N303 A304 S305 G306 K307 T308 T309 Q334
BS05	ATP	V13 R16 N38 G41 K42 T43 T44 Q71 K378 M382 S384 G386 E387	V11 R14 N36 G39 K40 T41 T42 Q69 K376 M380 S382 G384 E385
BS06	MG	T43 Q71	T41 Q69
BS07	MG	T310 Q336	T308 Q334

Gene Ontology

	Molecular Function
GO:0005524	ATP binding
GO:0016887	ATP hydrolysis activity

View graph for
Molecular Function

External links

PDB	RCSB:7nhn, PDBe:7nhn, PDBj:7nhn
PDBsum	7nhn
PubMed	34117249
UniProt	Q8Y8I3

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