Structure of PDB 7enj Chain 0

Receptor sequence
>7enj0 (length=267) Species: 9606 (Homo sapiens) [Search protein sequence]
VSVNLEAFSQAISAIQALRSSVSRVFDCLKDGMRNKETLEGREKAFIAHF
QDNLHSVNRDLNELERLSNLVGKLYSQLLQAYKWSNKLQYHAGLASGLLN
QQSLKRSANQMLVLPPQYVDDVISRIDRMFPEMSIHLSRPNGTSAMLLVT
LGKVLKVIVVMRSLFIDRTIVKGYNENVYTEDGKLDIWSKSNYQVFQKVT
DHATTALLHYQLPQMPDVVVRSFMTWLRSYIKLFQAPCQRCGKFLQDGLP
PTWRDFRTLEAFHDTCR
3D structure
PDB7enj Structures of the human Mediator and Mediator-bound preinitiation complex.
Chain0
Resolution4.4 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ZN 0 C281 H306 C309 C238 H263 C266
Gene Ontology
Molecular Function
GO:0003713 transcription coactivator activity
GO:0005515 protein binding
GO:0061630 ubiquitin protein ligase activity
Biological Process
GO:0006357 regulation of transcription by RNA polymerase II
GO:0006367 transcription initiation at RNA polymerase II promoter
GO:0016567 protein ubiquitination
GO:0032968 positive regulation of transcription elongation by RNA polymerase II
GO:0035019 somatic stem cell population maintenance
GO:0051123 RNA polymerase II preinitiation complex assembly
GO:0060261 positive regulation of transcription initiation by RNA polymerase II
Cellular Component
GO:0000151 ubiquitin ligase complex
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005667 transcription regulator complex
GO:0005730 nucleolus
GO:0005829 cytosol
GO:0016592 mediator complex
GO:0070847 core mediator complex

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:7enj, PDBe:7enj, PDBj:7enj
PDBsum7enj
PubMed33958484
UniProtQ6P2C8|MED27_HUMAN Mediator of RNA polymerase II transcription subunit 27 (Gene Name=MED27)

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