Structure of PDB 6wm2 Chain 0

Receptor sequence
>6wm20 (length=204) Species: 9606 (Homo sapiens) [Search protein sequence]
MTGLALLYSGVFVAFWACALAVGVCYTIFDLGFRFDVAWFLTETSPFMWS
NLGIGLAISLSVVGAAWGIYITGSSIIGGGVKAPRIKTKNLVSIIFCEAV
AIYGIIMAIVISNMAEPFSATDPKAIGHRNYHAGYSMFGAGLTVGLSNLF
CGVCVGIVGSGAALADAQNPSLFVKILIVEIFGSAIGLFGVIVAILQTSR
VKMG
3D structure
PDB6wm2 Structures of a Complete Human V-ATPase Reveal Mechanisms of Its Assembly.
Chain0
Resolution3.1 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 WSS 0 A21 Y26 L31 A21 Y26 L31
BS02 WSS 0 C25 F29 D30 C25 F29 D30
BS03 WSS 0 Y26 F35 D36 W39 Y26 F35 D36 W39
BS04 WSS 0 G3 L6 G3 L6
BS05 WSS 0 G32 D36 A38 G32 D36 A38
Gene Ontology
Molecular Function
GO:0005515 protein binding
GO:0015078 proton transmembrane transporter activity
GO:0046961 proton-transporting ATPase activity, rotational mechanism
Biological Process
GO:0007035 vacuolar acidification
GO:0007042 lysosomal lumen acidification
GO:0016241 regulation of macroautophagy
GO:0048388 endosomal lumen acidification
GO:0051452 intracellular pH reduction
GO:0061795 Golgi lumen acidification
GO:1902600 proton transmembrane transport
Cellular Component
GO:0000139 Golgi membrane
GO:0000220 vacuolar proton-transporting V-type ATPase, V0 domain
GO:0005765 lysosomal membrane
GO:0005768 endosome
GO:0005886 plasma membrane
GO:0010008 endosome membrane
GO:0016020 membrane
GO:0030665 clathrin-coated vesicle membrane
GO:0030670 phagocytic vesicle membrane
GO:0031410 cytoplasmic vesicle
GO:0033176 proton-transporting V-type ATPase complex
GO:0033177 proton-transporting two-sector ATPase complex, proton-transporting domain
GO:0033179 proton-transporting V-type ATPase, V0 domain

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:6wm2, PDBe:6wm2, PDBj:6wm2
PDBsum6wm2
PubMed33065002
UniProtQ99437|VATO_HUMAN V-type proton ATPase 21 kDa proteolipid subunit c'' (Gene Name=ATP6V0B)

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