Structure of PDB 8juu Chain B Binding Site BS46

Receptor Information
>8juu Chain B (length=4308) Species: 10116 (Rattus norvegicus) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
ECGSGNFRCDNGYCIPASWRCDGTRDCLDDTDEIGCPPRSCESGLFLCPA
EGTCIPSSWVCDEDKDCSDGADEQQNCAKEFECGSGECILRAYVCDHDND
CEDNSDERNCNYDTCGGHQFTCSNGQCINQNWVCDGDDDCQDSGDEDGCE
SNQSHHRCYPREWACPGSGRCISIDKVCDGVPDCPEGDDENNVTSGRTCG
MGVCSVLNCEYQCHQTPFGGECFCPPGHIINSNDSRTCIDFDDCQIWGIC
DQKCENRQGRHQCLCEEGYILERGQHCKSSDSFSAASVIFSNGRDLLVGD
LHGRNFRILAESKNRGMVMGVDFHYQKHRVFWTDPMQEKVFSTDINGLNT
QEILNVSVDTPENLAVDWINNKLYLVETKVNRIDVVNLEGNQRVTLITEN
LGHPRGIALDPTVGYLFFSDWGSLSGQPKVERAFMDGSNRKDLVTTKVGW
PAGITLDLVSKRVYWVDSRYDYIETVTYDGIQRKTVARGGSLVPHPFGIS
LFEEHVFFTDWTKMAVMKASKFTETNPQVYHQSSLRPHGVTVYHALRQPN
ATNPCGSNNGGCAQVCVLSHRTDNGGLGYRCKCEFGFELDDDEHRCVAVK
NFLLFSSKTAVRGIPFTLSTQEDVMVPVTGSPSFFVGIDFDAQHSTVFYS
DLSKDIIYKQKIDGTGKEVITANRLESVECLTFDWISRNLYWTDGGLKSV
TVLRLADKSRRQIISNLNNPRSIVVHPTAGYMFLSDWFRPAKIMRAWSDG
SHLMPIVNTSLGWPNGLAIDWSASRLYWVDAFFDKIEHSTLDGLDRKRLG
HVDQMTHPFGLTVFKDNVFITDWRLGAIIRVRKSDGGDMTVIRRGISSVM
HVKAYDADLQTGSNYCSQTTHANGDCSHFCFPVPNFQRVCGCPYGMKLQR
DQMTCEGDPAREPPTQQCGSLSFPCNNGKCVPSFFRCDGVDDCHDNSDEH
QCGVFNNTCSPSAFACVRGGQCIPGQWHCDRQNDCLDGSDEQNCPTHATS
STCPSTSFTCDNHVCIPKDWVCDTDNDCSDGSDEKNCQASGTCQPTQFRC
PDHRCISPLYVCDGDKDCADGSDEAGCVLNCTSAQFKCADGSSCINSRYR
CDGVYDCRDNSDEAGCPTRPPGMCHLDEFQCQGDGTCIPNTWECDGHPDC
IHGSDEHTGCVPKTCSPTHFLCDNGNCIYKAWICDGDNDCRDMSDEKDCP
TQPFHCPSTQWQCPGYSTCINLSALCDGVFDCPNGTDESPLCNQDSCSHF
NGGCTHQCMQGPFGATCLCPLGYQLANDTKTCEDINECDIPGFCSQHCVN
MRGSFRCACDPEYTLESDGRTCKVTGSENPLLVVASRDKIIVDNITAHTH
NLYSLVQDVSFVVALDFDSVTGRVFWSDLLQGKTWSVFQNGTDKRVVHDS
GLSVTEMIAVDWIGRNLYWTDYALETIEVSKIDGSHRTVLISKNVTKPRG
LALDPRMGDNVMFWSDWGHHPRIERASMDGTMRTVIVQEKIYWPCGLSID
YPNRLIYFMDAYLDYIEFCDYDGHNRRQVIASDLVLHHPHALTLFEDFVY
WTDRGTRQVMQANKWHGGNQSVVMYSVHQPLGITAIHPSRQPPSRNPCAS
ASCSHLCLLSAQAPRHYSCACPSGWNLSDDSVNCVRGDQPFLMSVRDNII
FGISLDPEVKSNDAMVPISGIQHGYDVEFDDSEQFIYWVENPGEIHRVKT
DGSNRTVFAPLSLLGSSLGLALDWVSRNIYYTTPASRSIEVLTLKGDTRY
GKTLIANDGTPLGVGFPVGIAVDPARGKLYWSDHGTDSGVPAKIASANMD
GTSLKILFTGNLQHLEVVTLDIQEQKLYWAVTSRGVIERGNVDGTERMIL
VHHLAHPWGLVVYGSFLYYSDEQYEVIERVDKSSGNNKVVLRDNVPYLRG
LRVYHRRNAADSSNGCSNNPNACQQICLPVPGGMFSCACASGFKLSPDGR
SCSPYNSFMVVSMLPAVRGFSLELSDHSEAMVPVAGQGRNVLHADVDVAN
GFIYWCDFSSSVRSSNGIRRIKPDGSNFTNVVTYGIGANGIRGVALDWAA
GNLYFTNAFVYETLIEVLRINTTYRRVLLKVSVDMPRHIIVDPKHRYLFW
ADYGQKPKIERSFLDCTNRTVLVSEGIVTPRGLAMDHDTGYIYWVDDSLD
LIARIHLDGGESQVVRYGSRYPTPYGITVFGESIIWVDRNLKKVFQASKQ
PGNTDPPVVIRDKINLLRDVTIFDEHAQPLSPAELNNNPCLQSNGGCSHF
CFALPELPTPRCGCAFGTLGNDGKSCATSQEDFLIYSLNNSLRSLHFDPR
DHSLPFQVISVAGTAIALDYDRRNNRIFFTQKLNSLRGQISYVSLYSGSS
SPTVLLSNIGVTDGIAFDWINRRIYYSDFSNQTINSMAEDGSNRAVIARV
SKPRAIVLDPCRGYMYWTDWGTNAKIERATLGGNFRVPIVNTSLVWPNGL
ALDLETDLLYWADASLQKIERSTLTGTNREVVVSTAFHSFGLTVYGQYIY
WTDLYTRKIYRANKYDGSDLVAMTTRLPTQPSGISTVVKTQRQQCSNPCD
QFNGGCSHICAPGPNGAECQCPHEGNWYLANDNKYCVVDTGTRCNQLQFT
CLNGHCINQDWKCDNDNDCGDGSDELPTVCAFHTCRSTAFTCGNGRCVPY
HYRCDYYNDCGDNSDEAGCLFRNCNSTTEFTCSNGRCIPLSYVCNGINNC
HDNDTSDEKNCPPHTCPPDFTKCQTTNICVPRAFLCDGDNDCGDGSDENP
IYCASHTCRSNEFQCLSPQRCIPSYWFCDGEADCADGSDEPDTCGHSVNT
CRASQFQCDNGRCISGNWVCDGDNDCGDMSDEDQRHHCELQNCSSTQFTC
VNSRPPNRRCIPQYWVCDGDADCSDALDELQNCTMRTCSAGEFSCANGRC
VRQSFRCDRRNDCGDYSDERGCSYPPCHANQFTCQNGRCIPRFFVCDEDN
DCGDGSDEQEHLCHTPEPTCPLHQFRCDNGHCIEMGRVCNHVDDCSDNSD
EKGCGINECLDSSISRCDHNCTDTITSFYCSCLPGYKLMSDKRSCVDIDE
CKESPQLCSQKCENVVGSYICKCAPGYIREPDGKSCRQNSNIEPYLIFSN
RYYIRNLTTDGSSYSLILQGLGNVVALDFDRVEKRLYWIDAEKQIIERMF
LNKTNRETIINHRLRRAESLAVDWVSRKLYWLDAILDCLFVSDLEGRHRK
MIAQHCVDANNTFCFEHPRGIVLHPQRGHVYWADWGVHAYIGRIGMDGTN
KSVIISTKIEWPNAITIDYTNDLLYWADAHLGYIEFSDLEGHHRHTVYDG
SLPHPFALTIFEDTVFWTDWNTRTVEKGNKYDGSGRVVLVNTTHKPFDIH
VYHPYRQPIMSNPCGTNNGGCSHLCLIKAGGRGFTCACPDDFQTVQLRDR
TLCMPMCSSTQFLCGNNEKCIPIWWKCDGQKDCSDGSDEPDLCPHRFCRL
GQFQCRDGNCTSPQALCNARQDCADGSDEDRVLCEHHRCESNEWQCANKR
CIPQSWQCDSVNDCLDNSDEDTSHCASRTCRPGQFKCNNGRCIPQSWKCD
VDNDCGDYSDEPIDECTTAAYNCDNHTEFSCKTNYRCIPQWAVCNGFDDC
RDNSDEQGCESVPCHPSGDFRCANHHCIPLRWKCDGTDDCGDNSDEENCV
PRECSESEFRCADQQCIPSRWVCDQENDCGDNSDERDCEMKTCHPEHFQC
TSGHCVPKALACDGRADCLDASDESACPTRFPNGTYCPAAMFECKNHVCI
QSFWICDGENDCVDGSDEEIHLCFNIPCESPQRFRCDNSRCVYGHQLCNG
VDDCGDGSDEKEEHCRKPTHKPCTDTEYKCSNGNCISQHYVCDNVNDCGD
LSDETGCNLGDNRTCAENICEQNCTQLSSGGFICSCRPGFKPSTLDKNSC
QDINECEEFGICPQSCRNSKGSYECFCVDGFKSMSTHYGERCAADGSPPL
LLLPENVRIRKYNTSSEKFSEYLEEEEHIQTIDYDWDPEHIGLSVVYYTV
LAQGSQFGAIKRAYIPNFESGSNNPIREVDLGLKYLMQPDGLAVDWVGRH
IYWSDAKSQRIEVATLDGRYRKWLITTQLDQPAAIAVNPKLGLMFWTDQG
KQPKIESAWMNGEHRSVLVSENLGWPNGLSIDYLNDDRVYWSDSKEDVIE
AIKYDGTDRRLIINEAMKPFSLDIFEDKLYWVAKEKGEVWRQNKFGKENK
EKVLVVNPWLTQVRIFHQLRYNQSVSNPCKQVCSHLCLLRPGGYSCACPQ
GSDFVTGSTVQCDAASELPVTMPPPCRCMHGGNCYFDENELPKCKCSSGY
SGEYCEVG
Ligand information
Ligand IDCA
InChIInChI=1S/Ca/q+2
InChIKeyBHPQYMZQTOCNFJ-UHFFFAOYSA-N
SMILES
SoftwareSMILES
CACTVS 3.341[Ca++]
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Ca+2]
FormulaCa
NameCALCIUM ION
ChEMBL
DrugBankDB14577
ZINC
PDB chain8juu Chain B Residue 4763 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB8juu Cryo-EM structures elucidate the multiligand receptor nature of megalin.
Resolution3.8 Å
Binding residue
(original residue number in PDB)		L3817 D3820 R3822 D3824 D3830 E3831
Binding residue
(residue number reindexed from 1)		L3710 D3713 R3715 D3717 D3723 E3724
Annotation score4
External links
PDB RCSB:8juu, PDBe:8juu, PDBj:8juu
PDBsum8juu
PubMed38771880
UniProtP98158|LRP2_RAT Low-density lipoprotein receptor-related protein 2 (Gene Name=Lrp2)

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