Structure of PDB 2rhp Chain A Binding Site BS21

Receptor Information
>2rhp Chain A (length=622) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
DGCLSNPCFPGAQCSSFPDGSWSCGFCPVGFLGNGTHCEDLDECALVPDI
CFSTSKVPRCVNTQPGFHCLPCPPRYRGNQPVGVGLEAAKTEKQVCEPEN
PCKDKTHNCHKHAECIYLGHFSDPMYKCECQTGYAGDGLICGEDSDLDGW
PSLNLVCATNATYHCIKDNCPHLPNSGQEDFDKDGIGDACDDDDDNDGVT
DEKDNCQLLFNPRQADYDKDEVGDRCDNCPYVHNPAQIDTDNNGEGDACS
VDIDGDDVFNERDNCPYVYNTDQRDTDGDGVGDHCDNCPLVHNPDQTDVD
NDLVGDQCDNNEDIDDDGHQNNQDNCPYISNANQADHDRDGQGDACDPDD
DNDGVPDDRDNCRLVFNPDQEDLDGDGRGDICKDDFDNDNIPDIDDVCPE
NNAISETDFRNFQMVPLDPKGTTQIDPNWVIRHQGKELVQTANSDPGIAV
GFDEFGSVDFSGTFYVNTDRDDDYAGFVFGYQSSSRFYVVMWKQVTQTYW
EDQPTRAYGYSGVSLKVVNSTTGTGEHLRNALWHTGNTPGQVRTLWHDPR
NIGWKDYTAYRWHLTHRPKTGYIRVLVHEGKQVMADSGPIYDQTYAGGRL
GLFVFSQEMVYFSDLKYECRDI
Ligand information
Ligand IDCA
InChIInChI=1S/Ca/q+2
InChIKeyBHPQYMZQTOCNFJ-UHFFFAOYSA-N
SMILES
SoftwareSMILES
CACTVS 3.341[Ca++]
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Ca+2]
FormulaCa
NameCALCIUM ION
ChEMBL
DrugBankDB14577
ZINC
PDB chain2rhp Chain A Residue 21 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB2rhp Influences of the N700S Thrombospondin-1 Polymorphism on Protein Structure and Stability.
Resolution2.9 Å
Binding residue
(original residue number in PDB)		D768 D770 D777 C779 V782 N784
Binding residue
(residue number reindexed from 1)		D218 D220 D227 C229 V232 N234
Annotation score4
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0005509 calcium ion binding
Biological Process
GO:0007155 cell adhesion
Cellular Component
GO:0005576 extracellular region

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:2rhp, PDBe:2rhp, PDBj:2rhp
PDBsum2rhp
PubMed18499674
UniProtP35442|TSP2_HUMAN Thrombospondin-2 (Gene Name=THBS2)

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