Structure of PDB 8jxg Chain A Binding Site BS18

Receptor Information
>8jxg Chain A (length=1114) Species: 10116 (Rattus norvegicus) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
PTRPPGMCHLDEFQCQGDGTCIPNTWECDGHPDCIHGSDEHTGCVPASHT
CRSNEFQCLSPQRCIPSYWFCDGEADCADGSDEPDTCGHSVNTCRASQFQ
CDNGRCISGNWVCDGDNDCGDMSDEDQRHHCELQNCSSTQFTCVNSRPPN
RRCIPQYWVCDGDADCSDALDELQNCTMRTCSAGEFSCANGRCVRQSFRC
DRRNDCGDYSDERGCSYPPCHANQFTCQNGRCIPRFFVCDEDNDCGDGSD
EQEHLCHTPEPTCPLHQFRCDNGHCIEMGRVCNHVDDCSDNSDEKGCGIN
ECLDSSISRCDHNCTDTITSFYCSCLPGYKLMSDKRSCVDIDECKESPQL
CSQKCENVVGSYICKCAPGYIREPDGKSCRQNSNIEPYLIFSNRYYIRNL
TTDGSSYSLILQGLGNVVALDFDRVEKRLYWIDAEKQIIERMFLNKTNRE
TIINHRLRRAESLAVDWVSRKLYWLDAILDCLFVSDLEGRHRKMIAQHCV
DANNTFCFEHPRGIVLHPQRGHVYWADWGVHAYIGRIGMDGTNKSVIIST
KIEWPNAITIDYTNDLLYWADAHLGYIEFSDLEGHHRHTVYDGSLPHPFA
LTIFEDTVFWTDWNTRTVEKGNKYDGSGRVVLVNTTHKPFDIHVYHPYRQ
PIMSNPCGTNNGGCSHLCLIKAGGRGFTCACPDDFQTVQLRDRTLCMPMC
SSTQFLCGNNEKCIPIWWKCDGQKDCSDGSDEPDLCPHRFCRLGQFQCRD
GNCTSPQALCNARQDCADGSDEDRVLCEHHRCESNEWQCANKRCIPQSWQ
CDSVNDCLDNSDEDTSHCASRTCRPGQFKCNNGRCIPQSWKCDVDNDCGD
YSDEPIDECTTAAYNCDNHTEFSCKTNYRCIPQWAVCNGFDDCRDNSDEQ
GCESVPCHPSGDFRCANHHCIPLRWKCDGTDDCGDNSDEENCVPRECSES
EFRCADQQCIPSRWVCDQENDCGDNSDERDCEMKTCHPEHFQCTSGHCVP
KALACDGRADCLDASDESACPTRFPNGTYCPAAMFECKNHVCIQSFWICD
GENDCVDGSDEEIHLCFNIPCESPQRFRCDNSRCVYGHQLCNGVDDCGDG
SDEKEEHCRKPTHK
Ligand information
Ligand IDCA
InChIInChI=1S/Ca/q+2
InChIKeyBHPQYMZQTOCNFJ-UHFFFAOYSA-N
SMILES
SoftwareSMILES
CACTVS 3.341[Ca++]
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Ca+2]
FormulaCa
NameCALCIUM ION
ChEMBL
DrugBankDB14577
ZINC
PDB chain8jxg Chain A Residue 4723 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB8jxg Cryo-EM structures elucidate the multiligand receptor nature of megalin.
Resolution3.2 Å
Binding residue
(original residue number in PDB)		W3739 D3742 T3744 D3746 D3752 E3753
Binding residue
(residue number reindexed from 1)		W925 D928 T930 D932 D938 E939
Annotation score4
External links
PDB RCSB:8jxg, PDBe:8jxg, PDBj:8jxg
PDBsum8jxg
PubMed38771880
UniProtP98158|LRP2_RAT Low-density lipoprotein receptor-related protein 2 (Gene Name=Lrp2)

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