Structure of PDB 5eul Chain A Binding Site BS15

Receptor Information
>5eul Chain A (length=746) Species: 224308 (Bacillus subtilis subsp. subtilis str. 168) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
RTLNRYEKIANDIDAIRGDYENLSDDALKHKTIEFKERLEKGATTDDLLV
EAFAVVREASRRVTGMFPFKVQLMGGVALHDGNIAEMKTGEGKTLTSTLP
VYLNALTGKGVHVVTVNEYLASRDAEQMGKIFEFLGLTVGLNLNSMSKDE
KREAYAADITYSTNNELGFDYLRDNMVLYKEQMVQRPLHFAVIDEVDSIL
IDEARTPLIISGQAAKSTKLYVQANAFVRTLKYTYDIKTKAVQLTEEGMT
KAEKAFGIDNLFDVKHVALNHHINQALKAHVAMQKDVDYVVEDGQVVIVD
SFTGRLMKGRRYSEGLHQAIEAKEGLEIQNESMTLATITFQNYFRMYEKL
AGMTGTAKTEEEEFRNIYNMQVVTIPTNRPVVRDDRPDLIYRTMEGKFKA
VAEDVAQRYMTGQPVLVGTVAVETSELISKLLKNKGIPHQVLNAKNHERE
AQIIEEAGQKGAVTIATNMAGTDIKLGEGVKELGGLAVVGTERHESRRID
NQLRGRSGRQGDPGITQFYLSMEDELMRRFGAERTMAMLDRFGMDDSTPI
QSKMVSRAVESSQKRVEGNNFDSRKQLLQYDDVLRQQREVIYKQRFEVID
EIVENMIKSSLERAIAAYMLELIMDRIITKYNEKEQMREFEKVIVLRAVD
SKWMDHIDAMDQLRQGIHLRGSKKTAIAIAVALAGFATVASYAQYEDGCS
GELERQHTFAGGPGAPLREYQMEGFAMFEHMIESIEDEVAKFVMKA
Ligand information
Ligand IDTBR
InChIInChI=1S/12BrH.6Ta/h12*1H;;;;;;/q;;;;;;;;;;;;;;;;;+1/p-1
InChIKeyYWYIQTPPCOBSGN-UHFFFAOYSA-M
SMILES
SoftwareSMILES
OpenEye OEToolkits 1.7.0Br[Ta]123456Br[Ta]17891%10[Ta]22%11(Br7)[Ta]337%12%13([Ta]484([Ta]923(Br%11)(Br1)(Br4)(Br7)Br%12)(Br5)(Br%10)Br%13)Br6
CACTVS 3.370Br|1[Ta]|2|3|4|5|Br[Ta]|6|7|89%10|2|Br[Ta]|%11|%12|%13|%14|1|3|6Br|[Ta]|%15|%16|%17|7|%11(Br|[Ta]|%18|4|%12|%15(Br|%13)(Br|%14)|Br[Ta]|5|8|%16|%18(|Br9)(Br)Br|%17)|Br%10
FormulaBr12 Ta6
NameHEXATANTALUM DODECABROMIDE;
DODECABROMOHEXATANTALUM
ChEMBL
DrugBankDB04119
ZINC
PDB chain5eul Chain A Residue 1017 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB5eul Crystal structure of a substrate-engaged SecY protein-translocation channel.
Resolution3.7 Å
Binding residue
(original residue number in PDB)		T376 K583 E586 G587 F590
Binding residue
(residue number reindexed from 1)		T359 K564 E567 G568 F571
Annotation score1
Enzymatic activity
Enzyme Commision number 7.4.2.8: protein-secreting ATPase.
Gene Ontology
Biological Process
GO:0006605 protein targeting
GO:0006886 intracellular protein transport
GO:0017038 protein import
Cellular Component
GO:0016020 membrane

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:5eul, PDBe:5eul, PDBj:5eul
PDBsum5eul
PubMed26950603
UniProtP28366|SECA_BACSU Protein translocase subunit SecA (Gene Name=secA)

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