Structure of PDB 8jxf Chain B Binding Site BS12

Receptor Information
>8jxf Chain B (length=1089) Species: 10116 (Rattus norvegicus) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
PTRPPGMCHLDEFQCQGDGTCIPNASHTCRSNEFQCLSPQRCIPSYWFCD
GEADCADGSDEPDTCGHSVNTCRASQFQCDNGRCISGNWVCDGDNDCGDM
SDEDQRHHCELQNCSSTQFTCVNSRPPNRRCIPQYWVCDGDADCSDALDE
LQNCTMRTCSAGEFSCANGRCVRQSFRCDRRNDCGDYSDERGCSYPPCHA
NQFTCQNGRCIPRFFVCDEDNDCGDGSDEQEHLCHTPEPTCPLHQFRCDN
GHCIEMGRVCNHVDDCSDNSDEKGCGINECLDSSISRCDHNCTDTITSFY
CSCLPGYKLMSDKRSCVDIDECKESPQLCSQKCENVVGSYICKCAPGYIR
EPDGKSCRQNSNIEPYLIFSNRYYIRNLTTDGSSYSLILQGLGNVVALDF
DRVEKRLYWIDAEKQIIERMFLNKTNRETIINHRLRRAESLAVDWVSRKL
YWLDAILDCLFVSDLEGRHRKMIAQHCVDANNTFCFEHPRGIVLHPQRGH
VYWADWGVHAYIGRIGMDGTNKSVIISTKIEWPNAITIDYTNDLLYWADA
HLGYIEFSDLEGHHRHTVYDGSLPHPFALTIFEDTVFWTDWNTRTVEKGN
KYDGSGRVVLVNTTHKPFDIHVYHPYRQPIMSNPCGTNNGGCSHLCLIKA
GGRGFTCACPDDFQTVQLRDRTLCMPMCSSTQFLCGNNEKCIPIWWKCDG
QKDCSDGSDEPDLCPHRFCRLGQFQCRDGNCTSPQALCNARQDCADGSDE
DRVLCEHHRCESNEWQCANKRCIPQSWQCDSVNDCLDNSDEDTSHCASRT
CRPGQFKCNNGRCIPQSWKCDVDNDCGDYSDEPIDECTTAAYNCDNHTEF
SCKTNYRCIPQWAVCNGFDDCRDNSDEQGCESVPCHPSGDFRCANHHCIP
LRWKCDGTDDCGDNSDEENCVPRECSESEFRCADQQCIPSRWVCDQENDC
GDNSDERDCEMKTCHPEHFQCTSGHCVPKALACDGRADCLDASDESACPT
RFPNGTYCPAAMFECKNHVCIQSFWICDGENDCVDGSDEEIHLCFNIPCE
SPQRFRCDNSRCVYGHQLCNGVDDCGDGSDEKEEHCRKP
Ligand information
Ligand IDCA
InChIInChI=1S/Ca/q+2
InChIKeyBHPQYMZQTOCNFJ-UHFFFAOYSA-N
SMILES
SoftwareSMILES
CACTVS 3.341[Ca++]
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Ca+2]
FormulaCa
NameCALCIUM ION
ChEMBL
DrugBankDB14577
ZINC
PDB chain8jxf Chain B Residue 4717 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB8jxf Cryo-EM structures elucidate the multiligand receptor nature of megalin.
Resolution3.6 Å
Binding residue
(original residue number in PDB)		W3532 D3535 Q3537 D3539 D3545 E3546
Binding residue
(residue number reindexed from 1)		W696 D699 Q701 D703 D709 E710
Annotation score4
External links
PDB RCSB:8jxf, PDBe:8jxf, PDBj:8jxf
PDBsum8jxf
PubMed38771880
UniProtP98158|LRP2_RAT Low-density lipoprotein receptor-related protein 2 (Gene Name=Lrp2)

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