Structure of PDB 8jxc Chain A Binding Site BS12

Receptor Information
>8jxc Chain A (length=1337) Species: 10116 (Rattus norvegicus) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
KEFECGSGECILRAYVCDHDNDCEDNSDERNCNYDTCGGHQFTCSNGQCI
NQNWVCDGDDDCQDSGDEDGCESNQSHHRCYPREWACPGSGRCISIDKVC
DGVPDCPEGDDENNVTSGRTCGMGVCSVLNCEYQCHQTPFGGECFCPPGH
IINSNDSRTCIDFDDCQIWGICDQKCENRQGRHQCLCEEGYILERGQHCK
SSDSFSAASVIFSNGRDLLVGDLHGRNFRILAESKNRGMVMGVDFHYQKH
RVFWTDPMQEKVFSTDINGLNTQEILNVSVDTPENLAVDWINNKLYLVET
KVNRIDVVNLEGNQRVTLITENLGHPRGIALDPTVGYLFFSDWGSLSGQP
KVERAFMDGSNRKDLVTTKVGWPAGITLDLVSKRVYWVDSRYDYIETVTY
DGIQRKTVARGGSLVPHPFGISLFEEHVFFTDWTKMAVMKASKFTETNPQ
VYHQSSLRPHGVTVYHALRQPNATNPCGSNNGGCAQVCVLSHRTDNGGLG
YRCKCEFGFELDDDEHRCVAVKNFLLFSSKTAVRGIPFTLSTQEDVMVPV
TGSPSFFVGIDFDAQHSTVFYSDLSKDIIYKQKIDGTGKEVITANRLESV
ECLTFDWISRNLYWTDGGLKSVTVLRLADKSRRQIISNLNNPRSIVVHPT
AGYMFLSDWFRPAKIMRAWSDGSHLMPIVNTSLGWPNGLAIDWSASRLYW
VDAFFDKIEHSTLDGLDRKRLGHVDQMTHPFGLTVFKDNVFITDWRLGAI
IRVRKSDGGDMTVIRRGISSVMHVKAYDADLQTGSNYCSQTTHANGDCSH
FCFPVPNFQRVCGCPYGMKLQRDQMTCEGDPAREPPTQQCGSLSFPCNNG
KCVPSFFRCDGVDDCHDNSDEHQCGVFNNTCSPSAFACVRGGQCIPGQWH
CDRQNDCLDGSDEQNCPTHATSSTCPSTSFTCDNHVCIPKDWVCDTDNDC
SDGSDEKNCQASGTCQPTQFRCPDHRCISPLYVCDGDKDCADGSDEAGCV
LNCTSAQFKCADGSSCINSRYRCDGVYDCRDNSDEAGCPTRPPGMCHLDE
FQCQGDGTCIPNTWECDGHPDCIHGSDEHTGCVPKTCSPTHFLCDNGNCI
YKAWICDGDNDCRDMSDEKDCPTQPFHDTGTRCNQLQFTCLNGHCINQDW
KCDNDNDCGDGSDELPTVCAFHTCRSTAFTCGNGRCVPYHYRCDYYNDCG
DNSDEAGCLFRNCNSTTEFTCSNGRCIPLSYVCNGINNCHDNDTSDEKNC
PPHTCPPDFTKCQTTNICVPRAFLCDGDNDCGDGSDENPIYCASHTCRSN
EFQCLSPQRCIPSYWFCDGEADCADGSDEPDTCGHSV
Ligand information
Ligand IDCA
InChIInChI=1S/Ca/q+2
InChIKeyBHPQYMZQTOCNFJ-UHFFFAOYSA-N
SMILES
SoftwareSMILES
CACTVS 3.341[Ca++]
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Ca+2]
FormulaCa
NameCALCIUM ION
ChEMBL
DrugBankDB14577
ZINC
PDB chain8jxc Chain A Residue 4721 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB8jxc Cryo-EM structures elucidate the multiligand receptor nature of megalin.
Resolution3.7 Å
Binding residue
(original residue number in PDB)		W1249 D1252 H1254 D1256 D1262 E1263
Binding residue
(residue number reindexed from 1)		W1064 D1067 H1069 D1071 D1077 E1078
Annotation score4
External links
PDB RCSB:8jxc, PDBe:8jxc, PDBj:8jxc
PDBsum8jxc
PubMed38771880
UniProtP98158|LRP2_RAT Low-density lipoprotein receptor-related protein 2 (Gene Name=Lrp2)

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