Structure of PDB 8jxa Chain A Binding Site BS12

Receptor Information
>8jxa Chain A (length=1077) Species: 10116 (Rattus norvegicus) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
PTRPPGMCHLDEFQCQGDGTCIPNTWECDGHPDCIHGSDEHTGCVPKTCG
HSVNTCRASQFQCDNGRCISGNWVCDGDNDCGDMSDEDQRHHCELQNCSS
TQFTCVNSRPPNRRCIPQYWVCDGDADCSDALDELQNCTMRTCSAGEFSC
ANGRCVRQSFRCDRRNDCGDYSDERGCSYPPCHANQFTCQNGRCIPRFFV
CDEDNDCGDGSDEQEHLCHTPEPTCPLHQFRCDNGHCIEMGRVCNHVDDC
SDNSDEKGCGINECLDSSISRCDHNCTDTITSFYCSCLPGYKLMSDKRSC
VDIDECKESPQLCSQKCENVVGSYICKCAPGYIREPDGKSCRQNSNIEPY
LIFSNRYYIRNLTTDGSSYSLILQGLGNVVALDFDRVEKRLYWIDAEKQI
IERMFLNKTNRETIINHRLRRAESLAVDWVSRKLYWLDAILDCLFVSDLE
GRHRKMIAQHCVDANNTFCFEHPRGIVLHPQRGHVYWADWGVHAYIGRIG
MDGTNKSVIISTKIEWPNAITIDYTNDLLYWADAHLGYIEFSDLEGHHRH
TVYDGSLPHPFALTIFEDTVFWTDWNTRTVEKGNKYDGSGRVVLVNTTHK
PFDIHVYHPYRQPIMSNPCGTNNGGCSHLCLIKAGGRGFTCACPDDFQTV
QLRDRTLCMPMCSSTQFLCGNNEKCIPIWWKCDGQKDCSDGSDEPDLCPH
RFCRLGQFQCRDGNCTSPQALCNARQDCADGSDEDRVLCEHHRCESNEWQ
CANKRCIPQSWQCDSVNDCLDNSDEDTSHCASRTCRPGQFKCNNGRCIPQ
SWKCDVDNDCGDYSDEPIDECTTAAYNCDNHTEFSCKTNYRCIPQWAVCN
GFDDCRDNSDEQGCESVPCHPSGDFRCANHHCIPLRWKCDGTDDCGDNSD
EENCVPRECSESEFRCADQQCIPSRWVCDQENDCGDNSDERDCEMKTCHP
EHFQCTSGHCVPKALACDGRADCLDASDESACPTRFPNGTYCPAAMFECK
NHVCIQSFWICDGENDCVDGSDEEIHLCFNIPCESPQRFRCDNSRCVYGH
QLCNGVDDCGDGSDEKEEHCRKPTHKP
Ligand information
Ligand IDCA
InChIInChI=1S/Ca/q+2
InChIKeyBHPQYMZQTOCNFJ-UHFFFAOYSA-N
SMILES
SoftwareSMILES
CACTVS 3.341[Ca++]
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Ca+2]
FormulaCa
NameCALCIUM ION
ChEMBL
DrugBankDB14577
ZINC
PDB chain8jxa Chain A Residue 4719 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB8jxa Cryo-EM structures elucidate the multiligand receptor nature of megalin.
Resolution3.8 Å
Binding residue
(original residue number in PDB)		A3572 N3575 R3577 D3579 D3585 E3586
Binding residue
(residue number reindexed from 1)		A720 N723 R725 D727 D733 E734
Annotation score4
External links
PDB RCSB:8jxa, PDBe:8jxa, PDBj:8jxa
PDBsum8jxa
PubMed38771880
UniProtP98158|LRP2_RAT Low-density lipoprotein receptor-related protein 2 (Gene Name=Lrp2)

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