Structure of PDB 8egw Chain B Binding Site BS10

Receptor Information

>8egw Chain B (length=424) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]

EPRQVFQVLEEQPPGTLVGTIQTRPGFTYRLSESHALFAINSSTGALYTT
STIDRESLPSDVINLVVLSSAPTYPTEVRVLVRDLNDNAPVFPDPSIVVT
FKEDSSSGRQVILDTATDSDIGSNGVDHRSYRIIRGNEAGRFRLDITLNP
SGEGAFLHLVSKGGLDREVTPQYQLLVEVEDKGEPKRRGYLQVNVTVQDI
NDNPPVFGSSHYQAGVPEDAVVGSSVLQVAAADADEGTNADIRYRLQDEG
TPFQMDPETGLITVREPLDFEARRQYSLTVQAMDRGVPSLTGRAEALIQL
LDVNDNDPVVKFRYFPATSRYASVDENAQVGTVVALLTVTDADSPAANGN
ISVQILGGNEQRHFEVQSSKVPNLSLIKVASALDRERIPSYNLTVSVSDN
YGAPPGAAVQARSSVASLVIFVND

Ligand information

Ligand ID

InChI

InChI=1S/Ca/q+2

InChIKey

BHPQYMZQTOCNFJ-UHFFFAOYSA-N

SMILES

Software	SMILES
CACTVS 3.341	[Ca++]
ACDLabs 10.04 OpenEye OEToolkits 1.5.0	[Ca+2]

Formula

Name

CALCIUM ION

PDB chain

8egw Chain B Residue 510 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]

Receptor-Ligand Complex Structure

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Structure summary

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PDB	8egw Structure of the planar cell polarity cadherins Fat4 and Dachsous1.
Resolution	2.3 Å
Binding residue (original residue number in PDB)	S412 K413
Binding residue (residue number reindexed from 1)	S369 K370
Annotation score	4

Enzymatic activity

Enzyme Commision number

Gene Ontology

	Molecular Function
GO:0005509	calcium ion binding

	Biological Process
GO:0007155	cell adhesion
GO:0007156	homophilic cell adhesion via plasma membrane adhesion molecules

	Cellular Component
GO:0005886	plasma membrane
GO:0016020	membrane

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Molecular Function

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Biological Process

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Cellular Component

External links

PDB	RCSB:8egw, PDBe:8egw, PDBj:8egw
PDBsum	8egw
PubMed	36797229
UniProt	Q6V0I7\|FAT4_HUMAN Protocadherin Fat 4 (Gene Name=FAT4)

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