Structure of PDB 6b9p Chain B Binding Site BS10

Receptor Information
>6b9p Chain B (length=929) Species: 3823 (Canavalia ensiformis) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
MKYNTGAGTVPEQLNVHLVPHSHDDVGWLKTVDQYYVGSENYIQEACVEN
VLDSVVMSLQRDPNRKFVFGEMAFFHRWWLEQTPETKELVRKLVKAGQLE
FVNGGWCMHDEATTHYIDMIDHTTLGHRFIQEQFNKIPRAGWQIDPFGHS
AVQGYLLGAELGFDSVHFARIDYQDREKRKAEKSLEVVWRGSKTFGSSAQ
IFANAFPGHYGPPNGFNFEVRNNFVPLQDDPRLFDTNVEERVQNFIDAAL
TQAKITRTNHIMWTMGDDFQYQYAESWFKQMDKLIHHVNKDGRVNALYST
PSIYTEAKNAANQTWPLKIDDYFPYADGRNAYWTGFYTSRSALKDYVRML
SGYYLATRQLGFFAGKKSTKYHAFDLADALGIAQHHDAVSGTAKQHTTND
YAKRLAIGASKAEAVVSSSLACLTSKCSAPASAFSQCHLFNISYCPPTES
SIPDDKSLVVVVYNPLGWSRNEIVRIPVNDANLVVKDSSGNKLEVQYVEM
DDVTANLRSFYVKAYEGEVPKDADVYWSLFKASVPPLGWSTYFISEALNI
GPGDLKMSFSSLTGQLKRMYNSKTGVDIPIQQNYLWYESSEGDFSDYQAS
GAYIFRPNSSVTRVTRGPLVDEVHQKFNSWISQVTRLYKDKDHAEIEFTI
GPIPTDDGVGKEVITRMTSTMATNKEFYTDSNGRDFLKRVRDYREDWPLE
VTQPVAGNYYPLNLGIYTKDEKSEFSVLVDRATGGASIKDGEVELMLHRR
TIRDDGRGVGEPLDEQVCMTCEGLTVRGNYYLSIHKPAAGSRWRRTTGQE
IYSPMLLAFTQENMENWKSSHSTKGIFMDPNYSLPPSVALITLEELDDGL
VLLRLAHLYEPSEDAEYSTLTKVELKKLFATQKIEELREVSLSANQEKSE
MKKMKWSVEGDDFVVELGPMEIRTFLLQF
Ligand information
Ligand IDZN
InChIInChI=1S/Zn/q+2
InChIKeyPTFCDOFLOPIGGS-UHFFFAOYSA-N
SMILES
SoftwareSMILES
CACTVS 3.341[Zn++]
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Zn+2]
FormulaZn
NameZINC ION
ChEMBLCHEMBL1236970
DrugBankDB14532
ZINC
PDB chain6b9p Chain B Residue 1002 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB6b9p Structural Basis of Outstanding Multivalent Effects in Jack Bean alpha-Mannosidase Inhibition.
Resolution1.996 Å
Binding residue
(original residue number in PDB)		H23 D25 D145 H386
Binding residue
(residue number reindexed from 1)		H23 D25 D145 H386
Annotation score4
Enzymatic activity
Enzyme Commision number 3.2.1.24: alpha-mannosidase.
Gene Ontology
Molecular Function
GO:0003824 catalytic activity
GO:0004559 alpha-mannosidase activity
GO:0016787 hydrolase activity
GO:0016798 hydrolase activity, acting on glycosyl bonds
GO:0030246 carbohydrate binding
GO:0046872 metal ion binding
Biological Process
GO:0005975 carbohydrate metabolic process
GO:0006013 mannose metabolic process
Cellular Component
GO:0000326 protein storage vacuole
GO:0005773 vacuole

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:6b9p, PDBe:6b9p, PDBj:6b9p
PDBsum6b9p
PubMed29722924
UniProtC0HJB3|MANA_CANEN Alpha-mannosidase

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