Structure of PDB 8ffz Chain A Binding Site BS10

Receptor Information
>8ffz Chain A (length=314) Species: 4932 (Saccharomyces cerevisiae) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
NRPKTYFCDYDGCDKAFTRPSILTEHQLSVHQGLRAFQCDKCAKSFVKKS
HLERHLYTHSDTKPFQCSYCGKGVTTRQQLKRHEVTHTKSFICPEEGCNL
RFYKHPQLRAHILSVHLHKLTCPHCNKSFQRPYRLRNHISKHHDPEVENP
YQCTFAGCCKEFRIWSQLQSHIKNDHPKLKCPICSKPCVGENGLQMHMII
HDDSLVTKNWKCHICPDMSFSRKHDLLTHYGSIHTEEDIPLELKYKISNN
NVEFLQNEVDLEKRLESGENGLNLLLNTVGRKYRCFYNNCSRTFKTKEKY
EKHIDKHKVHELKL
Ligand information
Ligand IDZN
InChIInChI=1S/Zn/q+2
InChIKeyPTFCDOFLOPIGGS-UHFFFAOYSA-N
SMILES
SoftwareSMILES
CACTVS 3.341[Zn++]
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Zn+2]
FormulaZn
NameZINC ION
ChEMBLCHEMBL1236970
DrugBankDB14532
ZINC
PDB chain8ffz Chain A Residue 508 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB8ffz Structural basis of TFIIIC-dependent RNA polymerase III transcription initiation.
Resolution3.8 Å
Binding residue
(original residue number in PDB)		C367 C372 H385 H389
Binding residue
(residue number reindexed from 1)		C285 C290 H303 H307
Annotation score4
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding
GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific
GO:0001002 RNA polymerase III type 1 promoter sequence-specific DNA binding
GO:0001010 RNA polymerase II sequence-specific DNA-binding transcription factor recruiting activity
GO:0003677 DNA binding
GO:0003723 RNA binding
GO:0008270 zinc ion binding
GO:0046872 metal ion binding
Biological Process
GO:0006355 regulation of DNA-templated transcription
GO:0006357 regulation of transcription by RNA polymerase II
GO:0042791 5S class rRNA transcription by RNA polymerase III
Cellular Component
GO:0005634 nucleus
GO:0005654 nucleoplasm

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:8ffz, PDBe:8ffz, PDBj:8ffz
PDBsum8ffz
PubMed37402369
UniProtP39933|TF3A_YEAST Transcription factor IIIA (Gene Name=PZF1)

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