Structure of PDB 6bx7 Chain A Binding Site BS10

Receptor Information

>6bx7 Chain A (length=429) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]

VVYKVPEEQPPNTLIGSLAADLYKLEVGAPYLRVDGKTGDIFTTETSIDR
EGLRECQNQLPGDPCILEFEVSITDLVQNGSPRLLEGQIEVQDINDNTPN
FASPVITLAIPENTNIGSLFPIPLASDRDAGPNGVASYELQAGPEAQELF
GLQVAEDQEEKQPQLIVMGNLDRERWDSYDLTIKVQDGGSPPRASSALLR
VTVLDTNDNAPKFERPSYEAELSENSPIGHSVIQVKANDSDQGANAEIEY
TFHQAPEVVRRLLRLDRNTGLITVQGPVDREDLSTLRFSVLAKDRGTNPK
SARAQVVVTVKDMNDNAPTIEIRGIGLVTHQDGMANISEDVAEETAVALV
QVSDRDEGENAAVTCVVAGDVPFQLRQASDSKKKYFLQTTTPLDYEKVKD
YTIEIVAVDSGNPPLSSTNSLKVQVVDVN

Ligand information

Ligand ID

InChI

InChI=1S/Ca/q+2

InChIKey

BHPQYMZQTOCNFJ-UHFFFAOYSA-N

SMILES

Software	SMILES
CACTVS 3.341	[Ca++]
ACDLabs 10.04 OpenEye OEToolkits 1.5.0	[Ca+2]

Formula

Name

CALCIUM ION

PDB chain

6bx7 Chain A Residue 511 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]

Receptor-Ligand Complex Structure

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Structure summary

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PDB	6bx7 Identification of an adhesive interface for the non-clustered delta 1 protocadherin-1 involved in respiratory diseases.
Resolution	2.85 Å
Binding residue (original residue number in PDB)	E349 D408 D441 V442
Binding residue (residue number reindexed from 1)	E339 D394 D427 V428
Annotation score	4

Enzymatic activity

Enzyme Commision number

Gene Ontology

	Molecular Function
GO:0005509	calcium ion binding

	Biological Process
GO:0007155	cell adhesion
GO:0007156	homophilic cell adhesion via plasma membrane adhesion molecules

	Cellular Component
GO:0005886	plasma membrane
GO:0016020	membrane

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Molecular Function

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Biological Process

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Cellular Component

External links

PDB	RCSB:6bx7, PDBe:6bx7, PDBj:6bx7
PDBsum	6bx7
PubMed	31583286
UniProt	Q08174\|PCDH1_HUMAN Protocadherin-1 (Gene Name=PCDH1)

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