Structure of PDB 5oxl Chain A Binding Site BS10

Receptor Information
>5oxl Chain A (length=448) Species: 264199 (Streptococcus thermophilus LMG 18311) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
GKTFFGQPLGLSTLFMTEMWERFSYYGMRAILLYYMWFLISTGDLHITRA
TAASIMAIYASMVYLSGTIGGFVADRIIGARPAVFWGGVLIMLGHIVLAL
PFGASALFGSIILIIIGTGFLKPNVSTLVGTLYDEHDRRRDAGFSIFVFG
INLGAFIAPLIVGAAQEAAGYHVAFSLAAIGMFIGLLVYYFGGKKTLDPH
YLRPTDPLAPEEVKPLLVKVSLAVAGFIAIIVVMNLVGWNSLPAYINLLT
IVAIAIPVFYFAWMTEHLRVVSYIPLFIAAVLFWAIEEQGSVVLATFAAE
RVDSSWFPVSWFQSLNPLFIMLYTPFFAWLWTAWPSSPTKFAVGLMFAGL
SFLLMAIPGALYGTSGKVSPLWLVGSWALVILGEMLISPVGLSVAFNSQM
MSMWFLSSSVGSALNAQLVTLYNAKSEVAYFSYFGLGSVVLGIVLVFL
Ligand information
Ligand IDLEU
InChIInChI=1S/C6H13NO2/c1-4(2)3-5(7)6(8)9/h4-5H,3,7H2,1-2H3,(H,8,9)/t5-/m0/s1
InChIKeyROHFNLRQFUQHCH-YFKPBYRVSA-N
SMILES
SoftwareSMILES
OpenEye OEToolkits 1.5.0CC(C)C[C@@H](C(=O)O)N
CACTVS 3.341CC(C)C[C@H](N)C(O)=O
OpenEye OEToolkits 1.5.0CC(C)CC(C(=O)O)N
ACDLabs 10.04O=C(O)C(N)CC(C)C
CACTVS 3.341CC(C)C[CH](N)C(O)=O
FormulaC6 H13 N O2
NameLEUCINE
ChEMBLCHEMBL291962
DrugBankDB00149
ZINCZINC000003645145
PDB chain5oxl Chain A Residue 517 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB5oxl Multispecific Substrate Recognition in a Proton-Dependent Oligopeptide Transporter.
Resolution2.66 Å
Binding residue
(original residue number in PDB)		R26 Y30 K126 I155 W296 W427
Binding residue
(residue number reindexed from 1)		R22 Y26 K122 I151 W284 W404
Annotation score4
Binding affinityPDBbind-CN: -logKd/Ki=3.25,Kd=0.56mM
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0022857 transmembrane transporter activity
GO:0042802 identical protein binding
GO:1904680 peptide transmembrane transporter activity
Biological Process
GO:0006857 oligopeptide transport
GO:0015833 peptide transport
GO:0055085 transmembrane transport
Cellular Component
GO:0005886 plasma membrane
GO:0016020 membrane

View graph for
Molecular Function
View graph for
Biological Process
View graph for
Cellular Component
External links
PDB RCSB:5oxl, PDBe:5oxl, PDBj:5oxl
PDBsum5oxl
PubMed29429879
UniProtQ5M4H8

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