Structure of PDB 5n0k Chain A Binding Site BS10

Receptor Information
>5n0k Chain A (length=1034) Species: 10116 (Rattus norvegicus) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
REKHYYIGITEAVWDYASGSEEKELISVDTEQSNFYLRNGPDRIGRKYKK
ALYSEYTDGTFTKTIDKPAWLGLLGPVIKAEVGDKVSVHVKNFASRPYTF
HAHGVTYTKANEGAIYPDNTTDFQRADDKLFPGQQYLYVLRANEPSPGEG
DSNCVTRIYHSHVDAPKDIASGLIGPLILCKKGSLHKEKEENIDQEFVLM
FSVVDENLSWYLEDNIKTFCSEPEKVDKDNEDFQESNRMYSINGYTFGSL
PGLSMCAEDRVKWYLFGMGNEVDVHSALFHGQALTSKNYHTDIINLFPAT
LIDVSMVAQNPGVWMLSCQNLNHLKAGLQAFFQVRDCNKPSPDDDIQDRH
VRHYYIAAEETIWDYAPSGTDTFTGENLTSLGSDSRVFFEQGATRIGGSY
KKLVYREYTDDSFTNRKQRGPDEEHLGILGPVIWAEVGDIIRVTFHNKGQ
FPLSIQPMGVRFTKENEGTYYGPDGRSSKQASHVAPKETFTYEWTVPKEM
GPTYADPVCLSKMYYSGVDLTKDIFTGLIGPMKICKKGSLLADGRQKDVD
KEFYLFATVFDENESLLLDDNIRMFTTAPENVDKEDEDFQESNKMHSMNG
FMYGNLPGLNMCLGESIVWYLFSAGNEADVHGIYFSGNTYLSKGERRDTA
NLFPHKSLTLLMTPDTEGSFDVECLTTDHYTGGMKQKYTVNQCKGQFEDV
TLYQGERTYYIAAVEVEWDYSPSRDWEMELHHLQEQNVSNAFLDKEEFFI
GSKYKKVVYREFTDSTFREQVKRRAEEEHLGILGPLIHADVGDKVKVVFK
NMASRPYSIHAHGVKTKSSTVAPTLPGEVRTYIWQIPERSGAGTEDSPCI
PWAYYSTVDRVKDLYSGLIGPLIVCRKSYVKVFNPKKKMEFSLLFLVFDE
NESWYLDDNINTYSDHPEKVNKDNEEFIESNKMHAINGKMFGNLQGLTMH
VGDEVNWYVMAMGNEIDLHTVHFHGHSFQYKHRGIHSSDVFDLFPGTYQT
LEMFPQTPGTWLLHCHVTDHIHAGMVTTYTVLPN
Ligand information
Ligand IDCA
InChIInChI=1S/Ca/q+2
InChIKeyBHPQYMZQTOCNFJ-UHFFFAOYSA-N
SMILES
SoftwareSMILES
CACTVS 3.341[Ca++]
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Ca+2]
FormulaCa
NameCALCIUM ION
ChEMBL
DrugBankDB14577
ZINC
PDB chain5n0k Chain A Residue 1111 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB5n0k Rat ceruloplasmin: a new labile copper binding site and zinc/copper mosaic.
Resolution2.3 Å
Binding residue
(original residue number in PDB)		K109 Q124 D127 D128
Binding residue
(residue number reindexed from 1)		K109 Q124 D127 D128
Annotation score1
Enzymatic activity
Enzyme Commision number 1.11.1.27: glutathione-dependent peroxiredoxin.
1.11.1.9: glutathione peroxidase.
1.16.3.1: ferroxidase.
1.16.3.4: cuproxidase.
Gene Ontology
Molecular Function
GO:0005507 copper ion binding
GO:0016491 oxidoreductase activity

View graph for
Molecular Function
External links
PDB RCSB:5n0k, PDBe:5n0k, PDBj:5n0k
PDBsum5n0k
PubMed29177316
UniProtP13635|CERU_RAT Ceruloplasmin (Gene Name=Cp)

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