Structure of PDB 2j5w Chain A Binding Site BS10

Receptor Information
>2j5w Chain A (length=1029) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
KEKHYYIGIIETTWDYASDHGEKKLISVDTEHSNIYLQNGPDRIGRLYKK
ALYLQYTDETFRTTIEKPVWLGFLGPIIKAETGDKVYVHLKNLASRPYTF
HSHGITYYKEHEGAIYPDNTTDFQRADDKVYPGEQYTYMLLATEEQSPGE
GDGNCVTRIYHSHIDAPKDIASGLIGPLIICKKDSLDKEKEKHIDREFVV
MFSVVDENFSWYLEDNIKTYCSEPEKVDKDNEDFQQSNRMYSVNGYTFGS
LSGLSMCAEDRVKWYLFGMGNEVDVHAAFFHGQALTNKNYRIDTINLFPA
TLFDAYMVAQNPGEWMLSCQNLNHLKAGLQAFFQVQECNKSSSKDNIRGK
HVRHYYIAAEEIIWNYAPSGIDIFTKENLTAPGSDSAVFFEQGTTRIGGS
YKKLVYREYTDASFTNRKERGPEEEHLGILGPVIWAEVGDTIRVTFHNKG
AYPLSIEPIGVRFNKNNEGTYYSPNVPPSASHVAPTETFTYEWTVPKEVG
PTNADPVCLAKMYYSAVDPTKDIFTGLIGPMKICKKGSLHANGRQKDVDK
EFYLFPTVFDENESLLLEDNIRMFTTAPDQVDKEDEDFQESNKMHSMNGF
MYGNQPGLTMCKGDSVVWYLFSAGNEADVHGIYFSGNTYLWRGERRDTAN
LFPQTSLTLHMWPDTEGTFNVECLTTDHYTGGMKQKYTVNQCRRQSEDST
FYLGERTYYIAAVEVEWDYSPQREWEKELHHLQEQNVSNAFLDKGEFYIG
SKYKKVVYRQYTDSTFRVPVERKAEEEHLGILGPQLHADVGDKVKIIFKN
MATRPYSIHAHGVQTESSTVTPTLPGETLTYVWKIPERSGAGTEDSACIP
WAYYSTVDQVKDLYSGLIGPLIVCRRPNPRRKLEFALLFLVFDENESWYL
DDNIKTYSDHPEKVNKDDEEFIESNKMHAINGRMFGNLQGLTMHVGDEVN
WYLMGMGNEIDLHTVHFHGHSFQYKHRGVYSSDVFDIFPGTYQTLEMFPR
TPGIWLLHCHVTDHIHAGMETTYTVLQNE
Ligand information
Ligand IDOXY
InChIInChI=1S/O2/c1-2
InChIKeyMYMOFIZGZYHOMD-UHFFFAOYSA-N
SMILES
SoftwareSMILES
CACTVS 3.341
OpenEye OEToolkits 1.5.0		O=O
FormulaO2
NameOXYGEN MOLECULE
ChEMBLCHEMBL1234886
DrugBankDB09140
ZINC
PDB chain2j5w Chain A Residue 3054 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB2j5w Ceruloplasmin Revisited: Structural and Functional Roles of Various Metal Cation-Binding Sites.
Resolution2.8 Å
Binding residue
(original residue number in PDB)		H101 H103 H161 H163 H978 H1022
Binding residue
(residue number reindexed from 1)		H101 H103 H161 H163 H966 H1010
Annotation score5
Enzymatic activity
Enzyme Commision number 1.11.1.27: glutathione-dependent peroxiredoxin.
1.11.1.9: glutathione peroxidase.
1.16.3.1: ferroxidase.
1.16.3.4: cuproxidase.
Gene Ontology
Molecular Function
GO:0005507 copper ion binding
GO:0016491 oxidoreductase activity

View graph for
Molecular Function
External links
PDB RCSB:2j5w, PDBe:2j5w, PDBj:2j5w
PDBsum2j5w
PubMed17242517
UniProtP00450|CERU_HUMAN Ceruloplasmin (Gene Name=CP)

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