Structure of PDB 1qhp Chain A Binding Site BS10

Receptor Information
>1qhp Chain A (length=686) Species: 1422 (Geobacillus stearothermophilus) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
SSSASVKGDVIYQIIIDRFYDGDTTNNNPAKSYGLYDPTKSKWKMYWGGD
LEGVRQKLPYLKQLGVTTIWLSPVLDNLDTLAGTDNTGYHGYWTRDFKQI
EEHFGNWTTFDTLVNDAHQNGIKVIVDFVPNHSTPFKANDSTFAEGGALY
NNGTYMGNYFDDATKGYFHHNGDISNWDDRYEAQWKNFTDPAGFSLADLS
QENGTIAQYLTDAAVQLVAHGADGLRIDAVKHFNSGFSKSLADKLYQKKD
IFLVGEWYGDDPGTANHLEKVRYANNSGVNVLDFDLNTVIRNVFGTFTQT
MYDLNNMVNQTGNEYKYKENLITFIDNHDMSRFLSVNSNKANLHQALAFI
LTSRGTPSIYYGTEQYMAGGNDPYNRGMMPAFDTTTTAFKEVSTLAGLRR
NNAAIQYGTTTQRWINNDVYIYERKFFNDVVLVAINRNTQSSYSISGLQT
ALPNGSYADYLSGLLGGNGISVSNGSVASFTLAPGAVSVWQYSTSASAPQ
IGSVAPNMGIPGNVVTIDGKGFGTTQGTVTFGGVTATVKSWTSNRIEVYV
PNMAAGLTDVKVTAGGVSSNLYSYNILSGTQTSVVFTVKSAPPTNLGDKI
YLTGNIPELGNWSTDTSGAVNNAQGPLLAPNYPDWFYVFSVPAGKTIQFK
FFIKRADGTIQWENGSNHVATTPTGATGNITVTWQN
Ligand information
Ligand IDCA
InChIInChI=1S/Ca/q+2
InChIKeyBHPQYMZQTOCNFJ-UHFFFAOYSA-N
SMILES
SoftwareSMILES
CACTVS 3.341[Ca++]
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Ca+2]
FormulaCa
NameCALCIUM ION
ChEMBL
DrugBankDB14577
ZINC
PDB chain1qhp Chain A Residue 697 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB1qhp X-ray structure of Novamyl, the five-domain "maltogenic" alpha-amylase from Bacillus stearothermophilus: maltose and acarbose complexes at 1.7A resolution.
Resolution1.7 Å
Binding residue
(original residue number in PDB)		N131 Q184 D198 H232
Binding residue
(residue number reindexed from 1)		N131 Q184 D198 H232
Annotation score4
Enzymatic activity
Catalytic site (original residue number in PDB) D127 R226 D228 E256 H328 D329
Catalytic site (residue number reindexed from 1) D127 R226 D228 E256 H328 D329
Enzyme Commision number 3.2.1.133: glucan 1,4-alpha-maltohydrolase.
Gene Ontology
Molecular Function
GO:0003824 catalytic activity
GO:0004556 alpha-amylase activity
GO:0030246 carbohydrate binding
GO:0043169 cation binding
GO:2001070 starch binding
Biological Process
GO:0005975 carbohydrate metabolic process

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Molecular Function
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Biological Process
External links
PDB RCSB:1qhp, PDBe:1qhp, PDBj:1qhp
PDBsum1qhp
PubMed10387084
UniProtP19531|AMYM_GEOSE Maltogenic alpha-amylase (Gene Name=amyM)

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