Structure of PDB 1mxg Chain A Binding Site BS10

Receptor Information

>1mxg Chain A (length=435) Species: 2262 (Pyrococcus woesei)

AKYLELEEGGVIMQAFYWDVPGGGIWWDHIRSKIPEWYEAGISAIWLPPP
SKGMSGGYSMGYDPYDYFDLGEYYQKGTVETRFGSKEELVRLIQTAHAYG
IKVIADVVINHRAGGDLEWNPFVGDYTWTDFSKVASGKYTANYLDFHPNE
LHCCDEGTFGGFPDICHHKEWDQYWLWKSNESYAAYLRSIGFDGWRFDYV
KGYGAWVVRDWLNWWGGWAVGEYWDTNVDALLSWAYESGAKVFDFPLYYK
MDEAFDNNNIPALVYALQNGQTVVSRDPFKAVTFVANHDTDIIWNKYPAY
AFILTYEGQPVIFYRDFEEWLNKDKLINLIWIHDHLAGGSTTIVYYDNDE
LIFVRNGDSRRPGLITYINLSPNWVGRWVYVPKFAGACIHEYTGNLGGWV
DKRVDSSGWVYLEAPPHDPANGYYGYSVWSYCGVG

Ligand information

• Ligand ID: MG
• InChI: InChI=1S/Mg/q+2
• InChIKey: JLVVSXFLKOJNIY-UHFFFAOYSA-N
• SMILES:
  ACDLabs 10.04
  OpenEye OEToolkits 1.5.0: [Mg+2]
  CACTVS 3.341: [Mg++]
• Formula: Mg
• Name: MAGNESIUM ION
• DrugBank: DB01378
• PDB chain: 1mxg Chain A Residue 441

Receptor-Ligand Complex Structure

Structure summary

• PDB: 1mxg Differential Regulation of a Hyperthermophilic alpha-Amylase with a Novel (Ca,Zn) Two-metal Center by Zinc
• Resolution: 1.6 Å
• Binding residue (original residue number in PDB): G24 E80 E88
• Binding residue (residue number reindexed from 1): G24 E80 E88
• Annotation score: 4

Enzymatic activity

• Catalytic site (original residue number in PDB): D198 E222 D289
• Catalytic site (residue number reindexed from 1): D198 E222 D289
• Enzyme Commision number: 3.2.1.1: alpha-amylase.

Gene Ontology

Molecular Function

• GO:0004553 hydrolase activity, hydrolyzing O-glycosyl compounds
• GO:0004556 alpha-amylase activity
• GO:0005509 calcium ion binding
• GO:0016798 hydrolase activity, acting on glycosyl bonds
• GO:0043169 cation binding
• GO:0046872 metal ion binding

Biological Process

• GO:0005975 carbohydrate metabolic process

External links

• PDB: RCSB:1mxg, PDBe:1mxg, PDBj:1mxg
• PDBsum: 1mxg
• PubMed: 12482867
• UniProt: Q7LYT7