Structure of PDB 8imx Chain G Binding Site BS09

Receptor Information
>8imx Chain G (length=579) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
RRALARLVLRLNAPLCVLSYVAGIAWFLALVFPPLTQRTYMSENAMGSTM
VEEQFAGGDRARAFARDFAAHRKKSGALPVAWLERTMRSVGLEVYTQSFS
RKLPFPDETHERYMVSGTNVYGILRAPRAASTESLVLTVPCGSDSTNSQA
VGLLLALAAHFRGQIYWAKDIVFLVTEHDLLGTEAWLEAYHDVNVTGMQS
SPLQGRAGAIQAAVALELSSDVVTSLDVAVEGLNGQLPNLDLLNLFQTFC
QKGGLLCTLQGKLQPEDWTSLDGPLQGLQTLLLMVLRQASGRPHGSHGLF
LRYRVEALTLRGINSFRQYKYDLVAVGKALEGMFRKLNHLLERLHQSFFL
YLLPGLSRFVSIGLYMPAVGFLLLVLGLKALELWMQLHEGLASLVAPLLI
SQAMGLALYVLPVLGQHVATQHFPVAEAEAVVLTLLAIYAAGLALPHNPD
RGWMALKLVALIYLALQLGCIALTNFSLGFLLATTMVPTAALAKPHGPRT
LYAALLVLTSPAATLLGSLFLWRELQEAPLSLAEGWQLFLAALAQGVLEH
HTYGALLFPLLSLGLYPCWLLFWNVLFWK
Ligand information
Ligand ID80Y
InChIInChI=1S/C8H18NO9P/c9-1-2-16-19(14,15)17-3-4-5(10)6(11)7(12)8(13)18-4/h4-8,10-13H,1-3,9H2,(H,14,15)/t4-,5-,6+,7+,8+/m1/s1
InChIKeyMMKGFVVPDOLYRA-HEIBUPTGSA-N
SMILES
SoftwareSMILES
CACTVS 3.385NCCO[P](O)(=O)OC[CH]1O[CH](O)[CH](O)[CH](O)[CH]1O
OpenEye OEToolkits 2.0.7C(COP(=O)(O)OCC1C(C(C(C(O1)O)O)O)O)N
OpenEye OEToolkits 2.0.7C(COP(=O)(O)OC[C@@H]1[C@H]([C@@H]([C@@H]([C@H](O1)O)O)O)O)N
CACTVS 3.385NCCO[P](O)(=O)OC[C@H]1O[C@H](O)[C@@H](O)[C@@H](O)[C@@H]1O
FormulaC8 H18 N O9 P
Name2-azanylethyl [(2R,3S,4S,5S,6S)-3,4,5,6-tetrakis(oxidanyl)oxan-2-yl]methyl hydrogen phosphate
ChEMBL
DrugBank
ZINC
PDB chain8imx Chain P Residue 103 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB8imx Structures of substrates- and products-bound glycosylphosphatidylinositol transamidase illuminate GPI-AP biogenesis
Resolution2.85 Å
Binding residue
(original residue number in PDB)		Y49 S51 Q355 S356 F357
Binding residue
(residue number reindexed from 1)		Y40 S42 Q346 S347 F348
Annotation score1
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0003923 GPI-anchor transamidase activity
GO:0005515 protein binding
GO:0015631 tubulin binding
GO:0034235 GPI anchor binding
Biological Process
GO:0006091 generation of precursor metabolites and energy
GO:0006506 GPI anchor biosynthetic process
GO:0006621 protein retention in ER lumen
GO:0008218 bioluminescence
GO:0016255 attachment of GPI anchor to protein
GO:0065003 protein-containing complex assembly
Cellular Component
GO:0005739 mitochondrion
GO:0005783 endoplasmic reticulum
GO:0005789 endoplasmic reticulum membrane
GO:0005813 centrosome
GO:0005829 cytosol
GO:0016020 membrane
GO:0042765 GPI-anchor transamidase complex

View graph for
Molecular Function
View graph for
Biological Process
View graph for
Cellular Component
External links
PDB RCSB:8imx, PDBe:8imx, PDBj:8imx
PDBsum8imx
PubMed37684232
UniProtO43292|GPAA1_HUMAN Glycosylphosphatidylinositol anchor attachment 1 protein (Gene Name=GPAA1)

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