Structure of PDB 8jxb Chain B Binding Site BS09

Receptor Information
>8jxb Chain B (length=1129) Species: 10116 (Rattus norvegicus) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
KEFECGSGECILRAYVCDHDNDCEDNSDERNCNYDTCGGHQFTCSNGQCI
NQNWVCDGDDDCQDSGDEDGCESNQSHHRCYPREWACPGSGRCISIDKVC
DGVPDCPEGDDENNVTSGRTCGMGVCSVLNCEYQCHQTPFGGECFCPPGH
IINSNDSRTCIDFDDCQIWGICDQKCENRQGRHQCLCEEGYILERGQHCK
SSDSFSAASVIFSNGRDLLVGDLHGRNFRILAESKNRGMVMGVDFHYQKH
RVFWTDPMQEKVFSTDINGLNTQEILNVSVDTPENLAVDWINNKLYLVET
KVNRIDVVNLEGNQRVTLITENLGHPRGIALDPTVGYLFFSDWGSLSGQP
KVERAFMDGSNRKDLVTTKVGWPAGITLDLVSKRVYWVDSRYDYIETVTY
DGIQRKTVARGGSLVPHPFGISLFEEHVFFTDWTKMAVMKASKFTETNPQ
VYHQSSLRPHGVTVYHALRQPNATNPCGSNNGGCAQVCVLSHRTDNGGLG
YRCKCEFGFELDDDEHRCVAVKNFLLFSSKTAVRGIPFTLSTQEDVMVPV
TGSPSFFVGIDFDAQHSTVFYSDLSKDIIYKQKIDGTGKEVITANRLESV
ECLTFDWISRNLYWTDGGLKSVTVLRLADKSRRQIISNLNNPRSIVVHPT
AGYMFLSDWFRPAKIMRAWSDGSHLMPIVNTSLGWPNGLAIDWSASRLYW
VDAFFDKIEHSTLDGLDRKRLGHVDQMTHPFGLTVFKDNVFITDWRLGAI
IRVRKSDGGDMTVIRRGISSVMHVKAYDADLQTGSNYCSQTTHANGDCSH
FCFPVPNFQRVCGCPYGMKLQRDQMTCEGDPAREPPTQQCGSLSFPCNNG
KCVPSFFRCDGVDDCHDNSDEHQCGVFNNTCSPSAFACVRGGQCIPGQWH
CDRQNDCLDGSDEQNCPTHATSSTCPSTSFTCDNHVCIPKDWVCDTDNDC
SDGSDEKNCQASGTCQPTQFRCPDHRCISPLYVCDGDKDCADGSDEAGCV
LNCTSAQFKCADGSSCINSRYRCDGVYDCRDNSDEAGCPTRPPGMCHLDE
FQCQGDGTCIPNTWECDGHPDCIHGSDEHTGCVPKTCSPTHFLCDNGNCI
YKAWICDGDNDCRDMSDEKDCPTQPFHCP
Ligand information
Ligand IDCA
InChIInChI=1S/Ca/q+2
InChIKeyBHPQYMZQTOCNFJ-UHFFFAOYSA-N
SMILES
SoftwareSMILES
CACTVS 3.341[Ca++]
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Ca+2]
FormulaCa
NameCALCIUM ION
ChEMBL
DrugBankDB14577
ZINC
PDB chain8jxb Chain B Residue 4717 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB8jxb Cryo-EM structures elucidate the multiligand receptor nature of megalin.
Resolution3.7 Å
Binding residue
(original residue number in PDB)		W1084 D1087 Q1089 D1091 D1097 E1098
Binding residue
(residue number reindexed from 1)		W899 D902 Q904 D906 D912 E913
Annotation score4
External links
PDB RCSB:8jxb, PDBe:8jxb, PDBj:8jxb
PDBsum8jxb
PubMed38771880
UniProtP98158|LRP2_RAT Low-density lipoprotein receptor-related protein 2 (Gene Name=Lrp2)

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