Structure of PDB 8jxa Chain A Binding Site BS09

Receptor Information
>8jxa Chain A (length=1077) Species: 10116 (Rattus norvegicus) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
PTRPPGMCHLDEFQCQGDGTCIPNTWECDGHPDCIHGSDEHTGCVPKTCG
HSVNTCRASQFQCDNGRCISGNWVCDGDNDCGDMSDEDQRHHCELQNCSS
TQFTCVNSRPPNRRCIPQYWVCDGDADCSDALDELQNCTMRTCSAGEFSC
ANGRCVRQSFRCDRRNDCGDYSDERGCSYPPCHANQFTCQNGRCIPRFFV
CDEDNDCGDGSDEQEHLCHTPEPTCPLHQFRCDNGHCIEMGRVCNHVDDC
SDNSDEKGCGINECLDSSISRCDHNCTDTITSFYCSCLPGYKLMSDKRSC
VDIDECKESPQLCSQKCENVVGSYICKCAPGYIREPDGKSCRQNSNIEPY
LIFSNRYYIRNLTTDGSSYSLILQGLGNVVALDFDRVEKRLYWIDAEKQI
IERMFLNKTNRETIINHRLRRAESLAVDWVSRKLYWLDAILDCLFVSDLE
GRHRKMIAQHCVDANNTFCFEHPRGIVLHPQRGHVYWADWGVHAYIGRIG
MDGTNKSVIISTKIEWPNAITIDYTNDLLYWADAHLGYIEFSDLEGHHRH
TVYDGSLPHPFALTIFEDTVFWTDWNTRTVEKGNKYDGSGRVVLVNTTHK
PFDIHVYHPYRQPIMSNPCGTNNGGCSHLCLIKAGGRGFTCACPDDFQTV
QLRDRTLCMPMCSSTQFLCGNNEKCIPIWWKCDGQKDCSDGSDEPDLCPH
RFCRLGQFQCRDGNCTSPQALCNARQDCADGSDEDRVLCEHHRCESNEWQ
CANKRCIPQSWQCDSVNDCLDNSDEDTSHCASRTCRPGQFKCNNGRCIPQ
SWKCDVDNDCGDYSDEPIDECTTAAYNCDNHTEFSCKTNYRCIPQWAVCN
GFDDCRDNSDEQGCESVPCHPSGDFRCANHHCIPLRWKCDGTDDCGDNSD
EENCVPRECSESEFRCADQQCIPSRWVCDQENDCGDNSDERDCEMKTCHP
EHFQCTSGHCVPKALACDGRADCLDASDESACPTRFPNGTYCPAAMFECK
NHVCIQSFWICDGENDCVDGSDEEIHLCFNIPCESPQRFRCDNSRCVYGH
QLCNGVDDCGDGSDEKEEHCRKPTHKP
Ligand information
Ligand IDCA
InChIInChI=1S/Ca/q+2
InChIKeyBHPQYMZQTOCNFJ-UHFFFAOYSA-N
SMILES
SoftwareSMILES
CACTVS 3.341[Ca++]
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Ca+2]
FormulaCa
NameCALCIUM ION
ChEMBL
DrugBankDB14577
ZINC
PDB chain8jxa Chain A Residue 4715 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB8jxa Cryo-EM structures elucidate the multiligand receptor nature of megalin.
Resolution3.8 Å
Binding residue
(original residue number in PDB)		A3291 D3294 E3323
Binding residue
(residue number reindexed from 1)		A439 D442 E471
Annotation score4
External links
PDB RCSB:8jxa, PDBe:8jxa, PDBj:8jxa
PDBsum8jxa
PubMed38771880
UniProtP98158|LRP2_RAT Low-density lipoprotein receptor-related protein 2 (Gene Name=Lrp2)

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