Structure of PDB 7c4c Chain A Binding Site BS09

Receptor Information

>7c4c Chain A (length=332) Species: 185431 (Trypanosoma brucei brucei TREU927)

SSMILKYPYRVVDTHEKLKEAVTSLQGARSIALDIEAFCTTDQAKQLGRI
SLVQACSDAKPVVFLFDVLTLTPDVFVKDMQSLLSDREIRKLFFDCRRDV
EALSCQLGVKPEGVLDLQVFFTAIQWKLRSVNRRSGMGYVLKSVAGLTRQ
EGDSAVQTAMTLGNRPVWDIRPLPDHFLEYAAGDVRHILLLSNYLVGNKD
VPVDVVAVERLTAQYVEHYAVGKPVITEADATPAEVNRAWLERYIGPGGG
CHFCGAKGHTEAECFKKQNGKAKCSFCGEVGHTARNCFKKHPQLLTCEKC
GQLGHTGTSCFRTNPCKHCGGPHSSANCHKVI

Ligand information

• Ligand ID: MN
• InChI: InChI=1S/Mn/q+2
• InChIKey: WAEMQWOKJMHJLA-UHFFFAOYSA-N
• SMILES:
  ACDLabs 10.04
  OpenEye OEToolkits 1.5.0: [Mn+2]
  CACTVS 3.341: [Mn++]
• Formula: Mn
• Name: MANGANESE (II) ION
• DrugBank: DB06757
• PDB chain: 7c4c Chain A Residue 411

Receptor-Ligand Complex Structure

Structure summary

• PDB: 7c4c Structural basis for guide RNA trimming by RNase D ribonuclease in Trypanosoma brucei.
• Resolution: 2.265 Å
• Binding residue (original residue number in PDB): A330 R331 K336 H337
• Binding residue (residue number reindexed from 1): A284 R285 K290 H291
• Annotation score: 4

Gene Ontology

Molecular Function

• GO:0000166 nucleotide binding
• GO:0000175 3'-5'-RNA exonuclease activity
• GO:0003676 nucleic acid binding
• GO:0008270 zinc ion binding
• GO:0008408 3'-5' exonuclease activity
• GO:0046872 metal ion binding

Biological Process

• GO:0006139 nucleobase-containing compound metabolic process

Cellular Component

• GO:0005739 mitochondrion
• GO:1990923 PET complex

External links

• PDB: RCSB:7c4c, PDBe:7c4c, PDBj:7c4c
• PDBsum: 7c4c
• PubMed: 33332555
• UniProt: Q38DE2