Structure of PDB 6meq Chain A Binding Site BS09

Receptor Information
>6meq Chain A (length=416) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
EPIRYAIPEELDRGSLVGNLAKDLGFGVGDLPTRNLRVIAEKKFFTVSPE
NGNLLVSDRIDREEICGKKSTCVLEFEMVAEKPLNFFHVTVLIQDINDNP
PTFSQNITELEISELALTGATFALESAQDPDVGVNSLQQYYLSPDPHFSL
IQKENLDGSRYPELVLKAPLDREEQPHHHLVLTAVDGGEPSRSCTTQIRV
IVADANDNPPVFTQDMYRVNVAENLPAGSSVLKVMAIDMDEGINAEIIYA
FINIGKEVRQLFKLDSKTGELTTIGELDFEERDSYTIGVEAKDGGHHTAY
CKVQIDISDENDNAPEITLASESQHIQEDAELGTAVALIKTHDLDSGFNG
EILCQLKGNFPFKIVQDTKNTYRLVTDGALDREQIPEYNVTITATDKGNP
PLSSSKTITLHILDAA
Ligand information
Ligand IDCA
InChIInChI=1S/Ca/q+2
InChIKeyBHPQYMZQTOCNFJ-UHFFFAOYSA-N
SMILES
SoftwareSMILES
CACTVS 3.341[Ca++]
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Ca+2]
FormulaCa
NameCALCIUM ION
ChEMBL
DrugBankDB14577
ZINC
PDB chain6meq Chain A Residue 509 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB6meq Interaction specificity of clustered protocadherins inferred from sequence covariation and structural analysis.
Resolution2.9 Å
Binding residue
(original residue number in PDB)		E114 E173 D204 A205 D207 D240
Binding residue
(residue number reindexed from 1)		E114 E173 D204 A205 D207 D240
Annotation score4
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0005509 calcium ion binding
Biological Process
GO:0007155 cell adhesion
GO:0007156 homophilic cell adhesion via plasma membrane adhesion molecules
Cellular Component
GO:0005886 plasma membrane
GO:0016020 membrane

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:6meq, PDBe:6meq, PDBj:6meq
PDBsum6meq
PubMed31431536
UniProtQ9Y5G1|PCDGF_HUMAN Protocadherin gamma-B3 (Gene Name=PCDHGB3)

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