Structure of PDB 1e40 Chain A Binding Site BS09

Receptor Information
>1e40 Chain A (length=483) Species: 1390 (Bacillus amyloliquefaciens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
VNGTLMQYFEWYTPNDGQHWKRLQNDAEHLSDIGITAVWIPPAYKGLSQS
DNGYGPYDLYDLGEFQQKGTVRTKYGTKSELQDAIGSLHSRNVQVYGDVV
LNHKAGADATEDVTAVEVNPANRNQETSEEYQIKAWTDFRFPGRGNTYSD
FKWHWYHFDGADWDESRKISRIFKFRGEGKAWDWEVSSENGNYDYLMYAD
VDYDHPDVVAETKKWGIWYANELSLDGFRIDAAKHIKFSFLRDWVQAVRQ
ATGKEMFTVAEYWQNNAGKLENYLNKTSFNQSVFDVPLHFNLQAASSQGG
GYDMRKLLNGTVVSKHPLKSVTFVDNHDTQPGQSLESTVQTWFKPLAYAF
ILTRESGYPQVFYGDMYGTKGDSQREIPALKHKIEPILKARKQYAYGAQH
DYFDHHDIVGWTREGDSSVANSGLAALITDGPGGAKRMYVGRQNAGETWH
DITGNRSEPVVINSEGWGEFHVNGGSVSIYVQR
Ligand information
Ligand IDTRS
InChIInChI=1S/C4H11NO3/c5-4(1-6,2-7)3-8/h6-8H,1-3,5H2/p+1
InChIKeyLENZDBCJOHFCAS-UHFFFAOYSA-O
SMILES
SoftwareSMILES
CACTVS 3.341[NH3+]C(CO)(CO)CO
ACDLabs 10.04OCC([NH3+])(CO)CO
OpenEye OEToolkits 1.5.0C(C(CO)(CO)[NH3+])O
FormulaC4 H12 N O3
Name2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL;
TRIS BUFFER
ChEMBL
DrugBank
ZINC
PDB chain1e40 Chain A Residue 601 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB1e40 Structural Analysis of a Chimeric Bacterial Alpha-Amylase. High Resolution Analysis of Native and Ligand Complexes
Resolution2.2 Å
Binding residue
(original residue number in PDB)		Y54 D231 E261 H327 D328
Binding residue
(residue number reindexed from 1)		Y54 D231 E261 H327 D328
Annotation score1
Enzymatic activity
Catalytic site (original residue number in PDB) R229 D231 E261 H327 D328
Catalytic site (residue number reindexed from 1) R229 D231 E261 H327 D328
Enzyme Commision number 3.2.1.1: alpha-amylase.
Gene Ontology
Molecular Function
GO:0004553 hydrolase activity, hydrolyzing O-glycosyl compounds
GO:0004556 alpha-amylase activity
GO:0005509 calcium ion binding
GO:0016798 hydrolase activity, acting on glycosyl bonds
GO:0046872 metal ion binding
Biological Process
GO:0005975 carbohydrate metabolic process
Cellular Component
GO:0005576 extracellular region

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:1e40, PDBe:1e40, PDBj:1e40
PDBsum1e40
PubMed10924103
UniProtP00692|AMY_BACAM Alpha-amylase

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