Structure of PDB 7w1m Chain H Binding Site BS08

Receptor Information
>7w1m Chain H (length=322) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
VSVYDFEEETFQCELCSYTCPRRSNLDRHMKSHTDERPHKCHLCGRAFRT
VTLLRNHLNTHTGTRPHKCPDCDMAFVTSGELVRHRRYKHTHEKPFKCSM
CDYASVEVSKLKRHIRSHTGERPFQCSLCSYASRDTYKLKRHMRTHSGEK
PYECYICHARFTQSGTMKMHILQKHTENVAKFHCPHCDTVIARKSDLGVH
LRKQHSYIEQGKKCRYCDAVFHERYALIQHQKSHKNEKRFKCDQCDYACR
QERHMIMHKRTHTGEKPYACSHCDKTFRQKQLLDMHFKRYHDPNFVPAAF
VCSKCGKTFTRRNTMARHADNC
Ligand information
Ligand IDZN
InChIInChI=1S/Zn/q+2
InChIKeyPTFCDOFLOPIGGS-UHFFFAOYSA-N
SMILES
SoftwareSMILES
CACTVS 3.341[Zn++]
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Zn+2]
FormulaZn
NameZINC ION
ChEMBLCHEMBL1236970
DrugBankDB14532
ZINC
PDB chain7w1m Chain H Residue 806 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB7w1m Cryo-EM structure of human cohesin-CTCF complex
Resolution6.5 Å
Binding residue
(original residue number in PDB)		H425 H430
Binding residue
(residue number reindexed from 1)		H170 H175
Annotation score4
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0000976 transcription cis-regulatory region binding
GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding
GO:0001221 transcription coregulator binding
GO:0001227 DNA-binding transcription repressor activity, RNA polymerase II-specific
GO:0003677 DNA binding
GO:0003682 chromatin binding
GO:0003700 DNA-binding transcription factor activity
GO:0005515 protein binding
GO:0008270 zinc ion binding
GO:0043035 chromatin insulator sequence binding
GO:0043565 sequence-specific DNA binding
GO:0046872 metal ion binding
GO:0140587 chromatin loop anchoring activity
GO:1990837 sequence-specific double-stranded DNA binding
Biological Process
GO:0000122 negative regulation of transcription by RNA polymerase II
GO:0001701 in utero embryonic development
GO:0006325 chromatin organization
GO:0006346 DNA methylation-dependent heterochromatin formation
GO:0006355 regulation of DNA-templated transcription
GO:0007005 mitochondrion organization
GO:0007059 chromosome segregation
GO:0007507 heart development
GO:0008285 negative regulation of cell population proliferation
GO:0010467 gene expression
GO:0010628 positive regulation of gene expression
GO:0010629 negative regulation of gene expression
GO:0040029 epigenetic regulation of gene expression
GO:0044027 negative regulation of gene expression via chromosomal CpG island methylation
GO:0045892 negative regulation of DNA-templated transcription
GO:0045893 positive regulation of DNA-templated transcription
GO:0045944 positive regulation of transcription by RNA polymerase II
GO:0055007 cardiac muscle cell differentiation
GO:0055013 cardiac muscle cell development
GO:0070602 regulation of centromeric sister chromatid cohesion
GO:0071459 protein localization to chromosome, centromeric region
GO:0071514 genomic imprinting
GO:0140588 chromatin looping
Cellular Component
GO:0000775 chromosome, centromeric region
GO:0000793 condensed chromosome
GO:0001673 male germ cell nucleus
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005694 chromosome
GO:0005730 nucleolus

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:7w1m, PDBe:7w1m, PDBj:7w1m
PDBsum7w1m
PubMed37536339
UniProtP49711|CTCF_HUMAN Transcriptional repressor CTCF (Gene Name=CTCF)

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