Structure of PDB 2a69 Chain F Binding Site BS08

Receptor Information

>2a69 Chain F (length=345) Species: 274 (Thermus thermophilus)

KISTSDPVRQYLHEIGQVPLLTLEEEVELARKVEEGMEAIKKLSEITGLD
PDLIREVVRAKILGSARVRHIPGLKETLDPKTVEEIDQKLKSLPKEHKRY
LHIAREGEAARQHLIEANLRLVVSIAKKYTGRGLSFLDLIQEGNQGLIRA
VEKFEYKRRFKFSTYATWWIRQAINRAIADQARTIRIPVHMVETINKLSR
TARQLQQELGREPTYEEIAEAMGPGWDAKRVEETLKIAQEPVSLETPIGD
EKDSFYGDFIPDEHLPSPVDAATQSLLSEELEKALSKLSEREAMVLKLRK
GLIDGEEVGAFFGVTRERIRQIENKALRKLKYHESRTRKLRDFLD

Ligand information

• Ligand ID: MG
• InChI: InChI=1S/Mg/q+2
• InChIKey: JLVVSXFLKOJNIY-UHFFFAOYSA-N
• SMILES:
  ACDLabs 10.04
  OpenEye OEToolkits 1.5.0: [Mg+2]
  CACTVS 3.341: [Mg++]
• Formula: Mg
• Name: MAGNESIUM ION
• DrugBank: DB01378
• PDB chain: 2a69 Chain F Residue 9390

Receptor-Ligand Complex Structure

Structure summary

• PDB: 2a69 Allosteric modulation of the RNA polymerase catalytic reaction is an essential component of transcription control by rifamycins.
• Resolution: 2.5 Å
• Binding residue (original residue number in PDB): R273 R276
• Binding residue (residue number reindexed from 1): R200 R203
• Annotation score: 4

Gene Ontology

Molecular Function

• GO:0003677 DNA binding
• GO:0003700 DNA-binding transcription factor activity
• GO:0016987 sigma factor activity
• GO:0046872 metal ion binding

Biological Process

• GO:0006352 DNA-templated transcription initiation
• GO:0006355 regulation of DNA-templated transcription
• GO:0010468 regulation of gene expression
• GO:2000142 regulation of DNA-templated transcription initiation

Cellular Component

• GO:0005737 cytoplasm

External links

• PDB: RCSB:2a69, PDBe:2a69, PDBj:2a69
• PDBsum: 2a69
• PubMed: 16096056
• UniProt: Q5SKW1