Structure of PDB 2z2y Chain C Binding Site BS08

Receptor Information

>2z2y Chain C (length=318) Species: 69014 (Thermococcus kodakarensis KOD1)

QPAQTIPWGIERVKAPSVWSITDGSVSVIQVAVLDTGVDYDHPDLAANIA
WCVSTLRGKVSTKLRDCADQNGHGTHVIGTIAALNNDIGVVGVAPGVQIY
SVRVLDARGSGSYSDIAIGIEQAILGPDGVADKDGDGIIAGDPDDDAAEV
ISMSLGGPADDSYLYDMIIQAYNAGIVIVAASGNEGAPSPSYPAAYPEVI
AVGAIDSNDNIASFSNRQPEVSAPGVDILSTYPDDSYETLMGTCMATPHV
SGVVALIQAAYYQKYGKILPVGTFDDISKNTVRGILHITADDLGPTGWDA
DYGYGVVRAALAVQAALG

Ligand information

• Ligand ID: ZN
• InChI: InChI=1S/Zn/q+2
• InChIKey: PTFCDOFLOPIGGS-UHFFFAOYSA-N
• SMILES:
  CACTVS 3.341: [Zn++]
  ACDLabs 10.04
  OpenEye OEToolkits 1.5.0: [Zn+2]
• Formula: Zn
• Name: ZINC ION
• ChEMBL: CHEMBL1236970
• DrugBank: DB14532
• PDB chain: 2z2y Chain C Residue 2003

Receptor-Ligand Complex Structure

Structure summary

• PDB: 2z2y Four new crystal structures of Tk-subtilisin in unautoprocessed, autoprocessed and mature forms: insight into structural changes during maturation
• Resolution: 1.89 Å
• Binding residue (original residue number in PDB): H153 C324
• Binding residue (residue number reindexed from 1): H73 C244
• Annotation score: 4

Enzymatic activity

• Catalytic site (original residue number in PDB): D115 H153 N264 C324
• Catalytic site (residue number reindexed from 1): D35 H73 N184 C244
• Enzyme Commision number: 3.4.21.-

Gene Ontology

Molecular Function

• GO:0004252 serine-type endopeptidase activity
• GO:0008236 serine-type peptidase activity

Biological Process

• GO:0006508 proteolysis

External links

• PDB: RCSB:2z2y, PDBe:2z2y, PDBj:2z2y
• PDBsum: 2z2y
• PubMed: 17706669
• UniProt: P58502|TKSU_THEKO Tk-subtilisin (Gene Name=TK1675)