Structure of PDB 7xeb Chain A Binding Site BS08

Receptor Information
>7xeb Chain A (length=533) Species: 673 (Grimontia hollisae) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
EQCDLSQFQTTSSNQLMAAIRQQGASCVNALFSADTGVQEAAFSSNHMYN
VAQYTRTLAQQYAGGGSDELEALYLYLRAGYYAEFYNSNITFLSWVTPAV
KGAVDAFVQNAHFYDNGDAHGKVLNEVIITMDSAGLQHAYLDVVTQWLTR
WNAQYAEHWYMRNAVNGVFTLLFGGQWNNQYTSLIGEQTALVTALQAFAL
DRTKVNSPTEFMAANAARELGRLARYTDATIAPKVTEGLTAIFGQYPSYG
DGDAIWLGAADTASYYADCSQFNICGFEDALRDAALNQTFICSDTIKIRS
QDMSQAQHLAACDKMAYEESFFHTTLETGNQPVADDHNTQLQVNIFNSDT
DYGKYAGPIFGIDTNNGGMYLEGNPANVGNIPNFIAYEASYANPDHFVWN
LEHEYVHYLDGRFNMYGDFGTPTELVVWWSEGVAEYVSRVNDNPQAIATI
QDGSTYTLAQVFDTTYDGFDVDRIYRWGYLAVRFMFERHPDEVQRMLSAT
RQGRWAEYKAIISGWANQYQSEFAQWTEALAKG
Ligand information
Ligand IDCA
InChIInChI=1S/Ca/q+2
InChIKeyBHPQYMZQTOCNFJ-UHFFFAOYSA-N
SMILES
SoftwareSMILES
CACTVS 3.341[Ca++]
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Ca+2]
FormulaCa
NameCALCIUM ION
ChEMBL
DrugBankDB14577
ZINC
PDB chain7xeb Chain A Residue 704 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB7xeb Crystal structure of Grimontia hollisae collagenase provides insights into its novel substrate specificity toward collagen.
Resolution2.39 Å
Binding residue
(original residue number in PDB)		T538 D541 S543
Binding residue
(residue number reindexed from 1)		T449 D452 S454
Annotation score4
Enzymatic activity
Enzyme Commision number 3.4.24.3: microbial collagenase.
Gene Ontology
Molecular Function
GO:0004222 metalloendopeptidase activity
GO:0008270 zinc ion binding
Biological Process
GO:0006508 proteolysis
Cellular Component
GO:0005576 extracellular region

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:7xeb, PDBe:7xeb, PDBj:7xeb
PDBsum7xeb
PubMed35679897
UniProtF7IZI6

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