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BioLiP

Structure of PDB 5eul Chain A Binding Site BS08

Receptor Information
>5eul Chain A (length=746) Species: 224308 (Bacillus subtilis subsp. subtilis str. 168) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
RTLNRYEKIANDIDAIRGDYENLSDDALKHKTIEFKERLEKGATTDDLLV
EAFAVVREASRRVTGMFPFKVQLMGGVALHDGNIAEMKTGEGKTLTSTLP
VYLNALTGKGVHVVTVNEYLASRDAEQMGKIFEFLGLTVGLNLNSMSKDE
KREAYAADITYSTNNELGFDYLRDNMVLYKEQMVQRPLHFAVIDEVDSIL
IDEARTPLIISGQAAKSTKLYVQANAFVRTLKYTYDIKTKAVQLTEEGMT
KAEKAFGIDNLFDVKHVALNHHINQALKAHVAMQKDVDYVVEDGQVVIVD
SFTGRLMKGRRYSEGLHQAIEAKEGLEIQNESMTLATITFQNYFRMYEKL
AGMTGTAKTEEEEFRNIYNMQVVTIPTNRPVVRDDRPDLIYRTMEGKFKA
VAEDVAQRYMTGQPVLVGTVAVETSELISKLLKNKGIPHQVLNAKNHERE
AQIIEEAGQKGAVTIATNMAGTDIKLGEGVKELGGLAVVGTERHESRRID
NQLRGRSGRQGDPGITQFYLSMEDELMRRFGAERTMAMLDRFGMDDSTPI
QSKMVSRAVESSQKRVEGNNFDSRKQLLQYDDVLRQQREVIYKQRFEVID
EIVENMIKSSLERAIAAYMLELIMDRIITKYNEKEQMREFEKVIVLRAVD
SKWMDHIDAMDQLRQGIHLRGSKKTAIAIAVALAGFATVASYAQYEDGCS
GELERQHTFAGGPGAPLREYQMEGFAMFEHMIESIEDEVAKFVMKA
Ligand information
Ligand IDTBR
InChIInChI=1S/12BrH.6Ta/h12*1H;;;;;;/q;;;;;;;;;;;;;;;;;+1/p-1
InChIKeyYWYIQTPPCOBSGN-UHFFFAOYSA-M
SMILES
SoftwareSMILES
OpenEye OEToolkits 1.7.0Br[Ta]123456Br[Ta]17891%10[Ta]22%11(Br7)[Ta]337%12%13([Ta]484([Ta]923(Br%11)(Br1)(Br4)(Br7)Br%12)(Br5)(Br%10)Br%13)Br6
CACTVS 3.370Br|1[Ta]|2|3|4|5|Br[Ta]|6|7|89%10|2|Br[Ta]|%11|%12|%13|%14|1|3|6Br|[Ta]|%15|%16|%17|7|%11(Br|[Ta]|%18|4|%12|%15(Br|%13)(Br|%14)|Br[Ta]|5|8|%16|%18(|Br9)(Br)Br|%17)|Br%10
FormulaBr12 Ta6
NameHEXATANTALUM DODECABROMIDE;
DODECABROMOHEXATANTALUM
ChEMBL
DrugBankDB04119
ZINC
PDB chain5eul Chain A Residue 1010 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB5eul Crystal structure of a substrate-engaged SecY protein-translocation channel.
Resolution3.7 Å
Binding residue
(original residue number in PDB)		E625 E628 I693
Binding residue
(residue number reindexed from 1)		E601 E604 I628
Annotation score1
Enzymatic activity
Enzyme Commision number 7.4.2.8: protein-secreting ATPase.
Gene Ontology
Biological Process
GO:0006605 protein targeting
GO:0006886 intracellular protein transport
GO:0017038 protein import
Cellular Component
GO:0016020 membrane

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:5eul, PDBe:5eul, PDBj:5eul
PDBsum5eul
PubMed26950603
UniProtP28366|SECA_BACSU Protein translocase subunit SecA (Gene Name=secA)

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