Structure of PDB 2z4t Chain A Binding Site BS08

Receptor Information

>2z4t Chain A (length=493) Species: 426532 (Photobacterium sp. JT-ISH-224) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]

TQSIIKNDINKTIIDEEYVNLEPINQSNISFTKHSWVQTCGTQQLLTEQN
KESISLSVVAPRLDDDEKYCFDFNGVSNKGEKYITKVTLNVVAPSLEVYV
DHASLPTLQQLMDIIKSEEENPTAQRYIAWGRIVPTDEQMKELNITSFAL
INNHTPADLVQEIVKQAQTKHRLNVKLSSNTAHSFDNLVPILKELNSFNN
VTVTNIDLYDDGSAEYVNLYNWRDTLNKTDNLKIGKDYLEDVINGINEDT
SNTGTSSVYNWQKLYPANYHFLRKDYLTLEPSLHELRDYIGDSLKQMQWD
GFKKFNSKQQELFLSIVNFDKQKLQNEYNSSNLPNFVFTGTTVWAGNHER
EYYAKQQINVINNAINESSPHYLGNSYDLFFKGHPGGGIINTLIMQNYPS
MVDIPSKISFEVLMMTDMLPDAVAGIASSLYFTIPAEKIKFIVFTSTETI
TDRETALRSPLVQVMIKLGIVKEENVLFWADLPNCETGVCIAV

Ligand information

Ligand ID

InChI

InChI=1S/Mg/q+2

InChIKey

JLVVSXFLKOJNIY-UHFFFAOYSA-N

SMILES

Software	SMILES
ACDLabs 10.04 OpenEye OEToolkits 1.5.0	[Mg+2]
CACTVS 3.341	[Mg++]

Formula

Name

MAGNESIUM ION

PDB chain

2z4t Chain A Residue 5002 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]

Receptor-Ligand Complex Structure

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Structure summary

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PDB	2z4t Crystal structure of Vibrionaceae Photobacterium sp. JT-ISH-224 alpha2,6-sialyltransferase in a ternary complex with donor product CMP and acceptor substrate lactose: catalytic mechanism and substrate recognition
Resolution	2.5 Å
Binding residue (original residue number in PDB)	E301 P302 S303
Binding residue (residue number reindexed from 1)	E280 P281 S282
Annotation score	4

Enzymatic activity

Enzyme Commision number

Gene Ontology

	Molecular Function
GO:0016757	glycosyltransferase activity
GO:0046872	metal ion binding

View graph for
Molecular Function

External links

PDB	RCSB:2z4t, PDBe:2z4t, PDBj:2z4t
PDBsum	2z4t
PubMed	17962295
UniProt	A8QYL1

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